Children of parents with type 2 diabetes, even if lean, exhibit insulin resistance and defects in the insulin signaling pathway, specifically at IRS1.

“they are resistant as their parents they have normal glucose tolerance why because their insul levels are astronomical and then we do a muscle bi how high just for understanding oh they're like two two two times uh normal even higher sometimes we do a muscle biopsy the same defect in the insulin signaling pathway how many of the how many of the tyrosine kyes defects do they have they have starts at irs1 insulin binding to the receptor is okay just like their parents the ability to activate the insulin signaling pathway the L IRS one it's already well established which enzyme in particular it starts at the level of irs1 starts at the first one oh so it's not just one enzyme though well no it's irs1 you can't tyrosine phosphorated you cannot activate pi3 Okay so it starts at irs1 Y”