Paul Saladino· MD
insulin resistance of skeletal muscle in glucose tolerant obese individuals is associated with reduced activity of oxidative enzymes and a disproportionate increase in the activity of glycolytic enzymes
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
insulin resistance of skeletal muscle in glucose tolerant obese individuals is associated with reduced activity of oxidative enzymes and a disproportionate increase in the activity of glycolytic enzymes
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so what they say is activity for glycolytic enzymes so these are the enzymes in glycolysis that don't go to cell respiration in terms of the creb cycle in the electron transfer chain was highest in non-insulin dependent diabetics and and then after that it was the obese people and then the lean people so highest in the diabetics medium activity in obesity and lowest in the lean people