Diabetic neuropathy and impaired microvasculature lead to poor wound healing and can result in amputations.

“there's something called diabetic neuropathy where the nerves simply don't work well and exposed to high glucose they lose their responsiveness and so sometimes people will for instance have a wound in their foot but they're not able to actually realize that they have that wound and so then they also have abnormal healing because the micro vasculature isn't behaving appropriately and the sum total can be very bad diabetic wounds that fail to get better with antibiotics and ultimately result in amputation”