Combining a liberal ketogenic diet with exogenous ketone supplementation may be an optimized approach for epilepsy, cancer, type 2 diabetes, and weight loss.

“So the ketones have a satiating effect on the brain. So the ketones are alternative energy substrate, and when your brain is metabolizing ketones, and it actually experiences low glucose, it doesn't go into an energetic crisis. So it's not signaling that you need to eat.”