SGTL2 inhibitors like Florin, which block glucose reabsorption in the kidney, are an effective approach to treating diabetes.

“so this is the sglt2 before you go to that Jason I'll just add another point to this because I know I discussed this with Jake Kushner several months ago but it's important to revisit this in case folks that have either forgotten that or didn't listen to it I want to emphasize what you just said a second ago because you said it's sort of like yeah we all know this but it's such an important point right when diabetes trials are using glycaemia as their endpoint meaning how low can you get the hemoglobin a1c how quote-unquote tightly can you control the glucose they do seem to have some benefits anything that is macrovascular does seem to get a little bit better so where glucose at high levels causes problems those things seem to get a little bit better but we're glucose at modest levels in the presence of high insulin sorry at the microf I said macro I meant micro vascular but the opposite is not true”