The polyol pathway is activated during hypoglycemia, leading to increased glucose uptake and AGE formation.

“in hypoglycemia conditions glucose concentration in insulin independent tissues such as neural tissue glomerulus which is the kidney the lens of the eye and the red blood cells the erthrocytes increases accordingly the polyol pathway is activated so basically what happens is in these cells that are having metabolic dysfunction in states of hypoglycemia you get this overflow of glucose into the cell and it upregulates glycolysis and subsequently the polyol pathway and some of that glucose from the hypoglycemia gets converted to fructose and then you're seeing the the possibility of age formation or Advanced glycation n product formation”