The formation of advanced glycation end products (AGEs) from fructose is primarily observed in individuals with diabetes due to altered intracellular metabolism, rather than being a direct consequence of dietary fructose consumption in healthy individuals.

“the formation of this this adduct or this addition of methylglyoxal to the mpk binding site to the Arginine groups has to happen inside the cell and so the question is why why are we having this high fructose inside the cell and when you start to look into the research what you start to uncover is that this is found specifically or theorized to be found specifically because this pathway is theoretical inside patients with diabetes and so this is actually what you are seeing is not a product of fructose consumption per se you're seeing this as a product of altered metabolism inside the diabetic cell leading to production of fructose inside the cell through something called the polyol pathway and then that's leading to the dysfunction”