Genetic variations associated with diseases of aging, including type 2 diabetes, late-onset Alzheimer's, frailty, and atherosclerosis, map to the p14ARF locus, which controls cellular senescence.

“one of the very big Peaks for diseases of aging maps into the control system for the establishment of cellular senescence is this p14 RF locus and you look at this is where this very important gene that people use for senescence all the time called p16 which is this part of the emergency break its gene lives in this locus and what you see is diseases like type 2 diabetes mutations that give rise to that live their mutations that give rise to late onset Alzheimer's live their frailty lives their atherosclerosis lives there”