Individuals with essential fructosuria, who lack fructokinase, have not been reported to have type 2 diabetes or obesity and appear to have normal or prolonged lifespan.

“yeah so there are people with a condition called the essential fructosyria where they are born without active fructokinase and they live normally no one's ever been reported to have type 2 diabetes or obesity so these people if i'm understanding you correctly are genetically immune to the harm of sugar yes and they pee out all the fructose yes okay so that seems to be an interesting topic this must be very rare i've never heard of it it's a rare condition they actually don't pee out all the fructose some fructose can be metabolized by an enzyme called hexokinase which is normally metabolized as glucose but fructose is preferentially metabolized by fructokinase so these people have very sweet urine going back to osler had he tasted their urine he would have confused them potentially with an even sweeter version than the people with ultimately type 2 diabetes that's how they were discovered because they would have reducing sugars which was fructose in their urine that was picked up with the old tests they used to use for diabetes but then they didn't have diabetes when they tested them and these people could literally just consume all the sugar they wanted and their uric acid is not going to go up their blood pressure is not going to go up their trigs don't go up they don't gain weight they don't become insulin resistant”