In the PROactive study, weight gain on pioglitazone predicted not dying from major adverse cardiovascular events.

“in the proactive study uh This was done long time ago you have to show cardiovascular safety 5,238 people to get in the study you had to have an MI stroke or something bad half people on pitone half the people on Placebo okay and uh the mace endpoint major adverse cardiovascular events which is non-fatal MI non-fatal stroke cardiovascular mortality you have to show the benefit to get approval by the FDA the the mace endpoint was POS okay uh and so uh when I talk to cardiologists I like to say what was the one thing uh in the pitzone that predicted that you would not die they don't know you know what the one thing that predicted that you wouldn't die weight gain H”