Methylated B vitamins, specifically methylcobalamin (B12) over cyanocobalamin, are beneficial for methylation, but some individuals can be sensitive to high doses of methylfolate, experiencing negative psychological symptoms.

“One supplement that a lot of people end up taking is L5 methylfolate or methylated B vitamins and when we say methyl A to B vitamins we generally mean a methyl form of cobalamin which is B12 relative to cyanocobalamin which is in most multivitamins not a great form of vitamin B12 to be eating because it contains a cyanide Mo so you don't need more cyanide in your body that is a mitochondrial toxin mitochondrial issues underly the majority of chronic diseases in humans so do not take cyanocobalamin if you want to take a B12 supplement a methyl adenos or hydroxy form is probably best there's some Nuance there depending on other genetic polymorphisms I'm going to have Gary bre on the podcast soon and we can dive into all of that with regards to catacol methyl transferase Etc in the polymorphism Spectrum but methyl ADB vitamins are great for some people some people like myself are quite sensitive to them when I take too much methyl folate I don't feel great I get a little angry I get irritable I've experimented with other forms of folate folinic acid being another one which is before the MTHFR step and too much of that doesn't make me feel great either so folate supplements can be tricky for people when they are methylated folate and some people can be sensitive to them in terms of psychological symptoms”