The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you give very high doses of vitamin C to people who are in this situation there's been some studies showing that in fulminant sepsis you can reduce the mortality rate from 40 percent to 8 percent by giving high doses of vitamin C
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A preliminary phase 2 trial found that treatment with intravenous vitamin C reduced mortality in patients with sepsis from 46% in the placebo group to ~30% in the vitamin C group at day 28.
the authors of the study noted a substantial difference in the death rates for the two groups whereas approximately 30 percent of patients who received the intravenous vitamin C died more than 46 percent of patients who took the placebo died
A separate study treated 47 patients with 6 grams of intravenous vitamin C four times per day for four days along with a steroid medication and vitamin b1 thiamine a control group of 47 patients identified as having similar baseline characteristics of sepsis when admitted to the intensive care unit received standard of care the death rate in the treated group was only 8.5 percent compared to 40.4% in the control group
a 2019 phase 2 clinical trial found that intravenous vitamin C reduce mortality in patients with sepsis and acute respiratory distress syndrome
these studies suggest that intravenous vitamin C administration might be beneficial in critically ill patients who have sepsis
patients who received vitamin C had fewer ventilated days spent less time in intensive care seven days versus ten and their hospital stays were approximately one week shorter than those who received the placebo
what's interesting is that the study revealed no differences in the primary outcomes of organ failure inflammation or vascular injury but 28 days after beginning of the study nearly half of the patients in the placebo group died compared to less than 30% in the intravenous vitamin C treated group
these studies suggest that intravenous vitamin C alone or in combination with other treatments like Thiemann decrease the risk of organ failure and death in patients diagnosed with sepsis
Some evidence suggests intravenous vitamin C might be an effective treatment for sepsis for example experimental studies in mice have demonstrated that intravenous vitamin C lessens the pro-inflammatory state associated with sepsis and preserves organ function
Furthermore patients in the vitamin C treated group had more ventilator free days were transferred out of the ICU at a higher rate and had seven more Hospital free days compared to the placebo group
roughly 40 percent of the patients in the control group died but roughly 8 percent of the patients in the vitamin C treated group died