Rhonda Patrick· PhD
Vitamin D plays a critical role in our body by activating the gene responsible for producing tryptophan hydroxylase 2 (TPH2), the enzyme that transforms the amino acid tryptophan into serotonin in the brain.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Vitamin D plays a critical role in our body by activating the gene responsible for producing tryptophan hydroxylase 2 (TPH2), the enzyme that transforms the amino acid tryptophan into serotonin in the brain.
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Vitamin D deficiency impairs the conversion of tryptophan into serotonin
For example, two enzymes important for the production of serotonin (TPH1 & TPH2) both contain this special sequence. This may be an important mechanism by which vitamin D affects brain function.
Vit. D is imp. to prevent gut conversion of tryp. to 5HT.
Vitamin D is required to synthesize serotonin from tryptophan.
It's on how vitamin D regulates serotonin: relevance for autism.
how Vitamin D hormone regulates serotonin and how this is relevant for autism so putting together this the autism puzzle this explained four different Char characteristics ass associated with autism the low vitamin D levels that are associated with autism explains the low serotonin levels in the brain but the high serotonin levels that are found in the gut uh and in the blood of autistics
the two SE separate genes both have a vitamin D response element but their their response elements were different they were functionally opposite to one another the one in the gut had a vitamin D response element that was an off signal meaning when vitamin D is PR present it shuts down the production of serotonin in the gut whereas the one in the brain had an on Signal meaning it activates or turns on um and produces the the production of serotonin in the brain
I recently found that the gene that encodes for the enzyme tryptophan hydroxylase which is the rate limiting en enzyme in the product in the conversion of tryptophan into serotonin has a vitamin D response element in it