Supplementing patients on phenytoin with vitamin D could mitigate the drug's negative impact on calcium absorption and bone health.

“I think the mechanism might have more to do with um like the liver inducing an enzyme called cytochrome P450 that leads to increased catabolism of vitamin D and that of course you may recall will lead to decreased uh absorption of calcium in the gut.”

“I think the mechanism might have more to do with um like the liver inducing an enzyme called cytochrome P450 that leads to increased catabolism of vitamin D and that of course you'll may recall will lead to decreased uh absorption of calcium in the gut.”