The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I think the mechanism might have more to do with um like the liver inducing an enzyme called cytochrome P450 that leads to increased catabolism of vitamin D and that of course you may recall will lead to decreased uh absorption of calcium in the gut.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I don't know if anybody's done a study, but it seems to me that a no-brainer study would be taking patients on phenitoin and supplementing them with lots of vitamin D to see if you can overcome that.
I think the mechanism might have more to do with um like the liver inducing an enzyme called cytochrome P450 that leads to increased catabolism of vitamin D and that of course you'll may recall will lead to decreased uh absorption of calcium in the gut.