Supplements typically contain only alpha-tocopherol, and megadosing alpha-tocopherol can deplete gamma-tocopherol levels.

“The major form of vitamin E that is found in supplements is Alpha tofol in fact supplements often leave out the gamma tofol form it's been shown that megadosing with high levels of alpha tofol can actually deplete your body's gamma tofol levels which is not a good thing this has been shown empirically so individuals that have been giving very high doses between 10 to 20 times the RDA somewhere like 400 IUS a day for two years has been shown to deplete gamma tofol Levels by as much as 50%”