Training that requires very high VO2 max outputs may lead cells to prioritize high output over metabolic efficiency over time, resulting in a loss of efficiency.

“there's actually a trade-off that if you're optimizing one physiological parameter it may come at the cost of the other physiological parameter that the training he did which we can sort of surmise must have been pretty good for increasing vo2 max because he got such a high one may have actually been bad for his economy not in the sense that his you know his legs were wobbling or he was had bad you know motion but at a metabolic level”

“there's actually a trade-off that if you're optimizing one physiological parameter it may come at the cost of the other physiological parameter that the training he did which we can sort of surmise must have been pretty good for increasing vo2 max because he got such a high one may have actually been bad for his economy not in the sense that his you know his legs were wobbling or he was had bad you know motion but at a metabolic level”

“you'll pay a slight penalty for for optimizing your training for vo2 max”

“if if your mitochondria are being stressed to the if you're if you're doing a lot of training that requires very high like vo2 max level outputs your your metabolism your cells need to make choices to produce high output instead of to be as be as efficient as possible and over time that's what you'll get better at and you'll lose that efficiency”