The Yamanaka factors can reset cells to a state resembling embryonic development.

“Magellan akka did he initially identified genes that as candidate list of genes that were turned on in this sort of embryo logical state and then he started using he was delivering the genes in various combinations he ultimately wound up paired down to about two dozen and then he then would take various pairwise combinations and figured out how few he could do and still manage to turn on one of these embryonic genes and he managed to weed it down to four and he got the Nobel Prize for that”