A single 25–30g dose of creatine not only reversed the cognitive deficits of 21 hours of s

Well SupportedSupplemental creatine can enhance cognitive function, particularly under conditions of high cognitive stress such as sleep deprivation, aging, or intense mental demands.

Well SupportedA dose of 20 grams of creatine taken acutely during periods of extreme stress like sleep deprivation or jet lag can improve memory, cognition, and brain creatine content.

Partially SupportedHigher creatine doses (10 grams) increase high-energy phosphates in brain gray matter, white matter, and thalamus, which are critical for mood, memory, and cognitive performance, particularly in individuals with treatment-resistant depression.