Being sedentary should be viewed as a disease. Nothing moves the needle more for longevity

Well SupportedFor men, each 10 mL/kg/minute increase in VO2 max is associated with a 17% lower risk of death from cancer and an 11% lower all-cause mortality.

Well SupportedImproving cardiorespiratory fitness can lead to significant improvements in mortality risk, comparable to or exceeding other major health interventions.

Well SupportedSedentarism is a disease that contributes to poor health, similar to obesity and type 2 diabetes.

Partially SupportedVigorous exercise improves cardiorespiratory fitness, particularly in individuals unresponsive to moderate-intensity exercise.