Animal-based vs. Ray Peat diet, a conversation with Georgi Dinkov

PS

Paul Saladino2h 5m · 2022-12-20

Claims Made

291

Claims Supported

247

Support Rate

85%

Support rate

247 of 291 claims supported

247 supported44 partial / not

Claims from this content

249

Well SupportedExcessive lipolysis and broken fat cells, potentially caused by polyunsaturated fatty acid breakdown products like linoleic acid, can lead to insulin resistance.Well SupportedOrgan meats are crucial for filling nutritional gaps not met by muscle meat or plants and are historically treasured for their nutrient density.Well SupportedAnimal liver is an excellent source of vitamin A, K2, B12, riboflavin, copper, zinc, iron, and choline.Well SupportedGround beef is beneficial partly because it contains collagen from chewy, sinewy parts of the animal.Well Supported

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Excess free fatty acids in the blood cause peripheral tissues to become insulin resistant, which is the direct cause of diabetes.

Well SupportedCombining carbohydrates with polyunsaturated fatty acids causes insulin resistance and weight gain.

Partially SupportedThe Hard Soil 'Whole Package' supplement is not Informed Sports certified because it contains naturally occurring testosterone and other androgens.

Not SupportedThe serotonin hypothesis of depression is not supported by evidence.

Well SupportedDiabetes and rising blood sugars are primarily caused by inappropriate gluconeogenesis from the liver being resistant to insulin's signals, not by excessive sugar intake.

Well SupportedMuscle meat is rich in tryptophan and methionine, while bone broth and collagenous tissues are rich in glycine, proline, and hydroxyproline.

Well SupportedSSRIs inhibit the activity of the serotonin transporter, slowing serotonin deactivation and increasing extracellular serotonin.

Well SupportedStarchy foods like bread, potatoes, pasta, and rice are problematic for humans due to gut inflammation and endotoxin production.

Well SupportedThe supplement 'Whole Package' from Heart and Soil Supplements can lead to noticeable results within hours, including increased energy, libido, and muscle density.

Well SupportedAdding organ meats to the diet can improve health.

Not SupportedPolyunsaturated fatty acids can break down into carcinogens and lead to chronic inflammation.

Well SupportedConsuming collagen with muscle meats can balance the inflammatory and anti-thyroid effects of certain amino acids.

Well SupportedIf increasing activity level leads to a low-carbohydrate state, carbohydrate intake must be adjusted to prevent health decline.

Well SupportedParticipants on 'The Biggest Loser' regained lost weight and experienced a ~40% decrease in basal metabolic rate.

Well SupportedIncreased free-floating tryptophan readily enters the brain and promotes serotonin production when unopposed by other large neutral amino acids.

Well SupportedIndividuals on a carbohydrate-deprived diet may experience lower testosterone and higher cortisol post-exercise.

Well SupportedA high NAD to NADH ratio favors pyruvate dehydrogenase activity, allowing glucose metabolism through the Krebs cycle.

Partially SupportedElevated prolactin levels are linked to breast cancer, and bromocriptine has shown a high cure rate for breast cancer.

Well SupportedApproximately 90% of serotonin is produced in the gut.

Partially SupportedCombining anti-cortisol treatment with anti-inflammatory drugs can enable very old individuals to build muscle at a rate comparable to people in their mid-20s.

Partially SupportedSerotonin is a primary controller of cortisol release, with cortisol production during exercise or stress being a downstream effect of serotonin synthesis.

Partially SupportedEating organs like animal testicles, hearts, and kidneys can be beneficial, particularly for male hypogonadism.

Well SupportedSalivary cortisol measurements may not correlate well with systemic cortisol levels and should be paired with blood or urinary cortisol tests.

Partially SupportedSoluble CD14 is a reliable biomarker of future mortality in individuals with HIV.

Partially SupportedSymptoms of very high serotonin include diarrhea, flushing, mental changes, psychosis, and depression.

Partially SupportedOptimal prolactin levels should be below the 50th percentile of the reference range, aiming for historic healthy male levels.

Well SupportedHigh levels of lipolysis and resulting free fatty acids block glucose uptake and the effects of insulin at the receptor level, preventing glucose metabolism.

Partially SupportedPathological insulin resistance can stem from chronic inflammation, high cortisol, or broken fat cells, potentially linked to seed oils.

Partially SupportedIncreasing serotonin with SSRIs or SNRIs can lead to a state of being unfeeling or chemically lobotomized.

Partially SupportedElevated extracellular serotonin can lead to blood clotting and fibrosis, and it inhibits the synthesis of dopamine by reducing tyrosine hydroxylase.

Partially SupportedIndividuals with diarrhea-predominant IBS may not tolerate spicy foods due to high serotonin.

Well SupportedAdequate gut serotonin production is necessary to maintain brain serotonin levels, impacting mood.

Well SupportedThe stomach and small intestine should ideally be free of bacteria before reaching the colon for proper nutrient absorption.

Partially SupportedElevated prolactin can be common in individuals with obesity or diabetes.

Partially SupportedEating well-cooked starch with saturated fat is metabolically acceptable.

Partially SupportedExcessively high DHEA in men may indicate adrenal hyperactivity or an adrenal tumor.

Partially SupportedProzac increases the brain synthesis of the neurosteroid allopregnanolone, which is a potent antidepressant.

Partially SupportedThe inflammatory reaction to endotoxin in the bloodstream closely resembles the reaction to other bacterial presences in the bloodstream.

Partially SupportedThe German FDA initially refused Prozac due to concerns about suicide, an admitted side effect in the first two weeks of SSRI use.

Partially SupportedCortisol levels four times the normal limit indicate a pathological state.

Partially SupportedInsulin resistance and diabetes can be caused by chronic inflammation leading to high cortisol levels, potentially exacerbated by cornstarch consumption.

Partially SupportedEnvironmental factors, particularly diet and eating habits, are more likely causes of obesity and diabetes than genetics.

Partially SupportedThe Randall cycle is primarily driven by the NAD to NADH ratio within mitochondria, which signals the cell's redox state and regulates pyruvate conversion to acetyl-CoA.

Partially SupportedAspirin and other NSAIDs have anabolic effects in the elderly because they inhibit the COX pathway.

Partially SupportedA cortisol blocker (mifepristone/RU-486) reversed insulin resistance and caused sustained weight loss in patients with Cushing's syndrome, suggesting cortisol is a primary driver of these conditions.

Partially SupportedLiver is a good source of zinc, copper, and selenium, especially when other food sources like seafood are limited.

Partially SupportedFree fatty acids can displace tryptophan from albumin, increasing free-floating tryptophan and potentially affecting brain entry.

Partially SupportedTlr4 activation triggers tryptophan hydroxylase, leading to serotonin production, with 90% of serotonin produced in the GI tract.

Partially SupportedThere are no well-conducted human studies demonstrating that fruit or fruit juice induce metabolic dysfunction.

Partially SupportedBlood-based cortisol tests may not accurately reflect adrenal function, whereas dried urine tests offer a more comprehensive view by measuring cortisol at multiple intervals and assessing metabolites.

Partially SupportedProzac acts as a partial antagonist at the serotonin 5-HT2C receptor, which drives cortisol production.

Partially SupportedEating connective tissues like tendons and ligaments, along with organs, is a practice of hunter-gatherer societies and beneficial for health.

Partially SupportedThe 'Whole Package' supplement is recommended for men to boost testosterone levels.

Partially SupportedProzac lowers cortisol levels and increases allopregnanolone, but at the cost of systemically elevated serotonin, which can lead to blood clotting, fibrosis, and other serotonin-associated issues.

Partially SupportedActivation of TLR4 by endotoxin triggers a cascade involving iNOS, leading to increased nitric oxide production.

Partially SupportedEndotoxin absorption into the bloodstream activates the TLR4 receptor, mimicking a direct bacterial injection.

Partially SupportedA ketogenic or low-carb diet can raise cortisol levels.

Partially SupportedWhen on a low-carb diet and potentially exercising, both factors can elevate cortisol as the brain synthesizes glucose from amino acids or fats when dietary sugar is unavailable.

Partially SupportedAn ounce of beef liver per day is a reasonable daily intake that avoids vitamin A toxicity concerns.

Partially SupportedInsufficient digestive enzymes or stomach acid can lead to undigested food reaching the colon, which is a pathological state.

Partially SupportedA mixture of raw or low-temperature pasteurized milk with maple syrup or honey and salt is palatable and beneficial.

Partially SupportedSerotonin is primarily produced in the gut, and gut irritation can increase serotonin levels.

Partially SupportedEight ounces of beef liver can provide 8-10mg of copper, which is well-tolerated and does not cause nausea or toxicity symptoms, unlike isolated copper supplements.

Partially SupportedFor individuals with a normal city lifestyle involving minimal movement, a macronutrient split of approximately 33% protein, 33% carbs, and 30% fat is advisable.

Partially SupportedConsuming approximately 20% of daily calories from fat is a good compromise that allows individuals to feel their best without excessive effort in label reading.

Partially SupportedWhole milk contains approximately 20-25 grams of lactose and 5 grams of fat per serving.

Partially SupportedExtremely low-fat diets can impair cholesterol synthesis and steroid production, potentially leading to low libido and mood issues.

Partially SupportedSimple carbohydrates like honey are preferable to starches if carbohydrates are desired, as they do not reach the colon to increase LPS production.

Partially SupportedHigh fructose corn syrup can contain up to 58% fructose, while sucrose is 50% glucose and 50% fructose.

Partially SupportedRestricting methionine intake to 2mg per kilogram of body weight per day can cure obesity and type 2 diabetes within weeks.

Partially SupportedBromocriptine, a drug for type 2 diabetes, acts as a dopamine agonist and serotonin antagonist, suggesting serotonin's role in diabetes.

Well SupportedSerotonin evolved as a metabolic regulator, not primarily as a 'happiness chemical'.

Partially SupportedCortisol is a pro-aging hormone and can reproduce the phenotype of aging when administered at high doses for extended periods.

Partially SupportedMetabolic disturbances in type 2 diabetes and obesity are largely driven by stored fat, particularly saturated fats.

Well SupportedIt is important to measure inflammation using multiple markers such as TNF alpha and IL-6, in addition to hs-CRP, for a comprehensive assessment.

Not SupportedThe efficacy of SSRIs and the serotonin hypothesis for depression are being questioned.

Partially SupportedLarge predators in Africa prioritize eating organs first when they kill an animal.

Not SupportedUltra running is likely not beneficial for human health as an organism, despite its potential for mental enjoyment or impressive feats of endurance.

Partially SupportedInsufficient glucose for the brain can elevate cortisol, leading to muscle, skin, and bone breakdown through liver gluconeogenesis.

Partially SupportedA 1:1 ratio of collagen to methionine, tryptophan, and cysteine from muscle meats is recommended for balancing inflammatory and anti-thyroid effects.

Partially SupportedElevated cortisol is a partial cause of diabetes, obesity, and other conditions.

Well SupportedTesting cortisol levels should ideally involve both AM and PM measurements, either through blood draws or salivary tests paired with 24-hour urine cortisol.

Partially SupportedStressful environments activate the HPA axis, increase cortisol and serotonin, which blunts pain and emotional responses but can be detrimental long-term.

Partially SupportedConsuming less than 20-28% of calories from fat may lead to fat cravings and issues with fat-soluble nutrient absorption.

Partially SupportedThe anabolic effect of steroids like testosterone is approximately 80% anti-catabolic, meaning they block cortisol's effects to allow muscle growth.

Partially SupportedProlactin levels are a strong surrogate for estrogen levels, as estrogen is a potent trigger for prolactin release.

Partially SupportedA high fat intake lowers the FAD to FADH2 ratio, impairing electron transport chain complex II activity and blocking glucose metabolism.

Partially SupportedSaturated fatty acids may act as an antagonist at toll-like receptor 4 (TLR4).

Partially SupportedIn a caloric deficit, increased cortisol relative to adrenaline leads to significant muscle mass loss over time.

Partially SupportedMost SSRI drugs are no better than placebo, with Prozac and Lexapro being exceptions.

Partially SupportedChronic fasting or exhaustive exercise can lead to highly elevated baseline cortisol production in animals.

Partially SupportedRestricting tryptophan, methionine, or cysteine, individually or in combination, can increase maximum lifespan by 20-30%.

Partially SupportedSerotonin drives fibrosis, which is a precursor stage to cancer.

Partially SupportedInhibitors of the lipoxygenase pathway, which produces leukotrienes, have reversed cognitive dysfunction in an animal model of Alzheimer's disease.

Partially SupportedBreakdown products of PUFAs, such as 4-HNE, are biomarkers for Alzheimer's, Parkinson's, and MS.

Partially SupportedMoving to environments like Costa Rica with better food, lower stress, sunshine, and nature can lead to visibly younger appearance and improved mood.

Partially SupportedObesity is an endocrine problem that should be evaluated by an endocrinologist, considering hormones like thyroid, cortisol, estrogen, and androgens.

Partially SupportedSufficient intake of antagonist amino acids present in collagen can provide longevity benefits similar to methionine restriction.

Partially SupportedConsuming approximately 40 grams of protein daily from gelatin, in addition to other protein sources, is a personal protocol.

Partially SupportedThe speaker plans to add whole blood serotonin to their next blood work panel.

Partially SupportedA 20% drop in brain ATP levels can lead to violent aggression.

Not SupportedEating only muscle meat can lead to an imbalance due to high levels of tryptophan, methionine, and cysteine, which are anti-thyroid and can inhibit thyroid hormone production.

Partially SupportedDeaminating 100 grams of amino acids daily produces approximately 60-70 grams of glucose.

Partially SupportedA diet exceeding 35% of calories from fat is considered a high-fat diet in animal research.

Partially SupportedConsuming organs, milk with honey and salt, and fruit may decrease one's taste for muscle meat.

Partially SupportedSubjective feelings of not feeling well are as valid as lab test results for assessing health.

Partially SupportedWorking extremely long hours contributes to health issues like diabetes.

Partially SupportedAs individuals age, androgens and thyroid hormones decline, while cortisol and serotonin levels do not, leading to a catabolic state exacerbated by stress.

Partially SupportedMaintaining baseline cortisol is crucial for muscle protein synthesis, while excessively low cortisol can lead to hypoglycemia and death.

Partially SupportedBromocriptine is commonly used to treat sexual dysfunction in males without other endocrine problems.

Partially SupportedEating while stressed can lead to glucose being converted to lactate or fat.

Partially SupportedChronically elevated serotonin via 5-HT2B receptor activation can cause fibrosis.

Partially SupportedBones contain approximately 40% collagen, which is composed of amino acids that can be used for synthesizing glucose.

Not SupportedKetogenic diets may be beneficial for 3-6 months but can lead to a significant crash and insulin resistance if continued long-term under chronic stress.

Partially SupportedMifepristone, a cortisol blocker, might be useful for treating diabetes.

Partially SupportedElevated LDH1 can indicate liver damage, while elevated LDH overall above 50% of the upper limit often indicates cancer.

Partially SupportedDamage to peripheral organs in type 2 diabetes is driven by elevated levels of free fatty acids, particularly polyunsaturated fats.

Partially SupportedThe speaker believes their ability to consume fruit and honey without negative metabolic consequences is achievable for others with proper lab work and understanding of their hormones and thyroid.

Not SupportedHigh serotonin levels in carcinoid syndrome do not prevent depression and psychosis.

Not SupportedSynthetic glucocorticoids like dexamethasone can cause insulin resistance, diabetes, heart attacks, strokes, neurodegenerative disease, and osteoporosis.

Not SupportedStrictly limiting carbohydrates can lead to a 'honeymoon period' followed by a progression to diabetes and the need for medication.

Partially SupportedConsuming BCAAs like leucine, isoleucine, and valine, along with tyrosine or phenylalanine, can decrease free tryptophan in the brain, leading to less serotonin production and consequently lowering cortisol levels.

Partially SupportedHumans typically do not synthesize significant amounts of lipids from carbohydrates until daily intake reaches approximately 500 grams.

Partially SupportedResistant starches increase LPS production and trigger TLR4 and serotonin, contributing to inflammation.

Partially SupportedA low NAD+ to NADH ratio impairs glucose metabolism by blocking key steps for ATP production.

Partially SupportedAdequate fat intake is necessary for the absorption of fat-soluble vitamins (A, K2, E) and cholesterol.

Partially SupportedStomach acid production is dependent on CO2 levels, which are influenced by metabolism.

Partially SupportedCooking bananas, such as grilling them, makes them more palatable.

Partially SupportedCooked bananas are a delicious way to consume starches with saturated fat.

Partially SupportedIncreasing intake of branched-chain amino acids or collagen can block the gut absorption of methionine.

Partially SupportedA good amount of muscle mass can be maintained without significant weightlifting, relying on adequate micronutrient intake and low stress hormones.

Partially SupportedModerate exercise like walking, pull-ups, push-ups, air squats, or climbing stairs can provide adequate stimulus for muscle maintenance.

Partially SupportedMeasuring whole blood serotonin levels is a relevant biomarker to consider for blood work.

Partially SupportedLactate dehydrogenase (LDH) is a useful biomarker for assessing inflammation and damage.

Partially Supported24-hour urinary cortisol is a good measure of cortisol levels, but it can be influenced by kidney function.

Not SupportedSSRIs and SNRIs can blunt emotional responses, potentially reducing the experience of health and increasing chronic disease risk.

Partially SupportedACP MOX, a derivative of vitamin B3, can normalize blood sugar and insulin levels in individuals with type 2 diabetes or insulin resistance.

Partially SupportedElevated endogenous cortisol can cause health problems similar to those caused by synthetic glucocorticoids.

Partially SupportedType 2 diabetes may be an endocrine disease similar to Cushing's syndrome, with cortisol playing a central role.

Partially SupportedTestosterone levels have declined precipitously over the last two to three decades, potentially contributing to increased obesity.

Partially SupportedIn men, accumulating abdominal fat often correlates with testosterone levels below 500 ng/dL, which is insufficient for natural conception.

Partially SupportedSerotonin is now considered the cause of psychosis, challenging the dopamine hypothesis.

Partially SupportedWell-cooked, non-resistant starches like potatoes and white rice, especially when consumed with saturated fat, are acceptable carbohydrate sources.

Partially SupportedGround beef with tendons and chewy bits may be beneficial for metabolic health.

Partially SupportedSaturated fats increase the production of tumor necrosis factor alpha and serotonin.

Partially SupportedSerotonin acts as a profibrotic mediator.

Not SupportedExcessive intake of PUFAs leads to pathology associated with chronic inflammation, high cortisol, and high estrogen.

Partially SupportedThe enzyme processing PUFA breakdown products can become substrate-dependent and increase chronic inflammation when exposed to excess PUFAs.

Partially SupportedMedications like cyproheptadine or audio 486 can cause extreme hunger by suppressing cortisol and leading to a drop in blood sugar.

Partially SupportedFeeding animals cornstarch can lead to an inflammatory reaction after nearly every meal.

Partially SupportedExperiencing a post-feeding stress reaction suggests a food or metabolic trigger is not being handled well.

Partially SupportedWhen cells are overloaded with fat, they cannot metabolize glucose, leading to pyruvate accumulation, NAD+ depletion, and increased lactate production, which is invariably seen in type 2 diabetes.

Partially SupportedElevated prolactin, even within the upper limit of the reference range, is associated with sexual dysfunction in men.

Partially SupportedSmall undissolved starch particles can be absorbed through the intestine, potentially triggering allergic or inflammatory reactions.

Partially SupportedBlood serotonin levels, not serum levels, are a key indicator for hormonal assessment.

Partially SupportedIndividuals with diabetes may benefit from consuming at least 100 grams of carbohydrates daily to prevent muscle loss and increased cortisol.

Partially SupportedSaturated fats are anti-metabolic, anti-glucose, pro-inflammatory, and synergize with estrogen and cortisol.

Partially SupportedCortisol activates aromatase and tryptophan hydroxylase, leading to increased estrogen and serotonin production, creating a positive feedback loop that further elevates cortisol.

Partially SupportedCortisol's primary effect, aside from agitation, is appetite suppression; drugs that suppress cortisol increase hunger.

Partially SupportedHigh levels of cortisol and stress hormones can impede muscle growth.

Partially SupportedAn ideal fat intake for the speaker is 30-35% of calories, though 20% is manageable.

Partially SupportedOverexertion in exercise increases stress hormones, contributing to a detrimental serotonin-cortisol cycle.

Partially SupportedLoss of lean muscle mass reduces basal metabolic rate, potentially leading to sarcopenic obesity.

Partially SupportedPure high fructose corn syrup should be metabolically indistinguishable from sucrose.

Partially SupportedPost-mortem studies of depressed individuals who committed suicide show elevated serotonin levels.

Partially SupportedLowering metabolism can negatively impact mood because higher cognitive functions are energy-dependent.

Partially SupportedSerotonin helps individuals endure unavoidable difficult times by blunting pain response and reducing sensitivity to unpleasant events.

Partially SupportedIf glucose cannot be metabolized, it is converted to lactate or fat, or excreted by the kidneys.

Partially SupportedTurbo ride acts as a dopamine receptor agonist and an antagonist of several serotonin receptors, particularly 5-HT2B.

Partially SupportedChronic stress and negative feedback loops can be beneficial for 3-6 months, after which individuals may hit a wall and experience a crash if they continue pushing themselves.

Partially SupportedElevated free fatty acids in the bloodstream can cause diabetic ketoacidosis and lactic acidosis, conditions with very high mortality rates requiring immediate high-dose insulin treatment.

Partially SupportedEating hearts from male animals can provide testosterone, with an average-sized beef heart potentially yielding 5-10mg of testosterone.

Partially SupportedLean meat consumption is not optimal for human health.

Partially SupportedAvoiding seed oils and favoring saturated fats from butter, milk, and red meat is important for metabolic health.

Partially SupportedMetabolizing sugars requires cofactors, particularly B vitamins like B3, B1, and B2.

Partially SupportedSome beverages with high fructose corn syrup may contain significant amounts of unprocessed starch, leading to a higher caloric value than labeled.

Partially SupportedThe body requires very little essential amino acids, orders of magnitude less than typically consumed.

Partially SupportedBlocking the 5-HT2C receptor can cure Cushing's syndrome by preventing the serotonin-driven cascade that raises ACTH.

Partially SupportedHigh serotonin levels during illness may inhibit ATP levels in the brain, potentially leading to irritability and aggression.

Partially SupportedDead gram-negative bacteria contain endotoxin (lipopolysaccharide), a molecule composed of fat and sugar, which is irritating to tissues including the intestinal wall.

Partially SupportedConsuming MCT oil mixed with honey is unlikely to cause fat gain and may promote a highly metabolic state.

Partially SupportedFor individuals who are obese or diabetic, limiting carbohydrates to 120 to 170 grams per day may be appropriate.

Partially SupportedConsuming pure fructose or sucrose, such as in high-fructose corn syrup, can deplete essential B vitamin cofactors.

Partially SupportedIncreased nitric oxide production can contribute to cardiovascular disease by generating toxic aldehydes that form arterial plaque.

Partially SupportedA high-fat diet impairs electron transport chain complex II function by dropping the FAD to FADH2 ratio.

Partially SupportedType 2 diabetes and obesity can be initiated by chronic high stress elevating cortisol or by a diet leading to obesity.

Partially SupportedExcessive fat intake contributes to fat gain and impairs glucose utilization.

Partially SupportedFor individuals struggling to lose weight, a fat intake cutoff of approximately 15% of daily calories is recommended.

Not SupportedPsychiatrists defend SSRI use by stating 'the dosage makes the poison' and not measuring serotonin levels in patients without carcinoid syndrome.

Partially SupportedProzac's beneficial effects are seen at microdosing levels that do not inhibit the serotonin transporter; higher doses have mixed effects.

Partially SupportedHaloperidol is a non-selective serotonin antagonist, making the link between serotonin and psychosis inconclusive.

Partially SupportedNitric oxide stimulates NF-kappa B (NFkB), the master regulator of the inflammatory cascade, leading to the activation of prostaglandins and inflammatory mediators.

Partially SupportedInflammation is a more easily checked indicator of issues affecting muscle synthesis than cortisol levels.

Partially SupportedSerotonin produced in the GI tract can affect the brain.

Partially SupportedIncreased absorption of endotoxin into the bloodstream can increase intestinal permeability.

Partially SupportedIf individuals eating a balanced diet still experience problems from natural sugars like honey and ripe fruit, an endocrinological issue is likely the cause.

Not SupportedExhaustive exercise is not ideal for individuals over 40, as their bodies are less capable of producing protective anti-catabolic hormones like dehydroepiandrosterone (DHEA) and pregnenolone.

Partially SupportedWeight gain after returning to a normal diet from a low-carb diet is due to the prior low-carb diet, not inherently because carbs make one fat.

Partially SupportedA low-fat diet (10% of calories from fat) can lead to significant fat mass loss and preservation of muscle mass over two to three years.

Partially SupportedIf lab results are normal, it is generally safe to assume the person is okay, as serious pathology would likely not resolve spontaneously.

Partially SupportedConsuming carbohydrates like honey and fruits can help break negative stress-related feedback cycles.

Not SupportedA very low-fat diet (5% of calories from fat) can lead to agitation, inability to sleep, and hunger.

Partially SupportedRed meats, particularly lean cuts, contain short-chain fatty acids that are metabolized similarly to sugar.

Partially SupportedIn high fat diets, glucose is largely converted into lactic acid or favors the fatty acid synthase pathway rather than being fully metabolized to ATP.

Partially SupportedAn equal ratio of macronutrients daily is likely a good approach for most people, unless they are very active, in which case carbohydrate intake should increase.

Partially SupportedMedium-chain triglycerides (MCTs) can be consumed at 100% of caloric intake without causing fat gain.

Partially SupportedIf cortisol is in range and diet is adequate, muscle synthesis should occur; otherwise, chronic inflammation or inflammatory cytokines/prostaglandins are likely causes.

Partially SupportedTryptophan is the sole precursor to serotonin, is directly carcinogenic, and is present in the smallest amount of any amino acid in living organisms.

Partially SupportedFree fatty acids block glucose metabolism and inhibit glucose uptake into cells.

Partially SupportedDrastically restricting methionine intake causes metabolic rate to increase.

Partially SupportedLiver is a rich source of minerals, fat-soluble vitamins, and B vitamins.

Partially SupportedHigh fat diets, characterized by increased lipolysis, reduce glucose uptake into cells by inhibiting glucose transporters that depend on insulin.

Partially SupportedThere may be an optimal amount of exertion in dieting and exercise, and excessive exertion does not necessarily lead to more gain.

Not SupportedTender cuts of meat like filet mignon may be metabolically worse than cuts with more tendons and sinew.

Partially SupportedIndividuals on a low-carbohydrate diet for over 11-12 months may experience edema, heart problems, or discontinue the diet due to intolerance.

Not SupportedPushing through a metabolic wall leads to collapse and metabolic decline.

Partially SupportedAspirin can block the gut absorption of methionine, tryptophan, and cysteine, potentially offering beneficial effects when taken semi-regularly.

Not SupportedFor individuals with non-alcoholic fatty liver disease, overconsumption of fat can lead to storage as triglycerides rather than liver processing.

Partially SupportedThe absence of shaking after a meal can indicate adequate reserves, glycogen levels, and a non-hyperglycemic or non-hyper-adrenal state.

Partially SupportedGaining weight and elevated triglycerides when consuming fruit and honey may indicate a damaged metabolic state or hormonal/thyroid issues.

Partially SupportedProstaglandins can be measured in blood to assess inflammatory state, as approximately 80% of the inflammatory reaction is driven by the COX pathway.

Partially SupportedEmergency medicine, surgery, and infectious disease medicine are effective.

Partially SupportedGeorgi Dinkov eats about half an ounce of liver almost daily and a pound of heart as often as possible.

Partially SupportedPeroxide breakdown products of PUFAs, including aldehydes like 4-HNE, are pathological and toxic, with 4-HNE being a carcinogen.

Partially SupportedNovel lipogenesis from sugar requires approximately 454 grams of sugar per day to initiate polymeric acid synthesis.

Partially SupportedWhen undigested food reaches the colon, the microbiome increases bacterial turnover, leading to the death of some bacteria.

Partially SupportedKidneys contain steroids and unique hydroxylated fatty acids that offer a protective effect against acute kidney injury.

Partially SupportedPhysicians may consider liver enzymes elevated up to two times the upper limit of normal as not immediately pathological.

Not SupportedSSRIs/SNRIs for depression may cause blunting similar to an anesthetic.

Partially SupportedTiny nanoparticles of starch entering the bloodstream may be responsible for inflammatory reactions that drive insulin resistance and Type 2 diabetes.

Partially SupportedChronic unpredictable mild stress in animal models is associated with depression, insulin resistance, and diabetes.

Partially SupportedSelective serotonin antagonists have shown efficacy in curing schizophrenia in clinical trials, suggesting serotonin's role in the condition.

Partially SupportedSerotonin antagonism is being investigated as a potential treatment for pulmonary fibrosis and heart failure.

Partially SupportedInterleukin-1 and Interleukin-6 antagonists are successful anti-aging drugs.

Not SupportedSerotonin lowers metabolic rate and increases tolerance to inhospitable circumstances.

Partially SupportedHumans typically do not begin synthesizing lipids from carbohydrates until they consume approximately 500 grams of carbs daily.

Partially SupportedHigh serotonin levels in sick individuals can lead to irritability and poor mood as a protective mechanism.

Partially SupportedProzac increases the synthesis of allopregnanolone, a protective neurosteroid, in the brain.

Partially SupportedA study found that individuals on intermittent fasting and low-carb diets lost lean muscle mass at alarming rates.

Partially SupportedMuch of the weight lost on a low-carb diet is water because cutting carbs mimics the effect of diuretics.

Partially SupportedMany chronic diseases stem from consuming foods with unlisted ingredients like cornstarch and high fructose corn syrup.

Partially SupportedMost people on a Western diet consume several grams of methionine per day, far exceeding the recommended amount for health benefits.

Partially SupportedStudies suggest honey consumption does not lead to metabolic unwellness in humans.

Partially SupportedThe upper limit for prolactin in males has been raised by US labs from 18 to 22 in recent years.

Partially SupportedType 2 diabetes is an endocrine disease largely driven by hyperlipidemia.