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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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The IGF-1 Trade-Off: Performance vs. Longevity — Whalespan

Content›Video›The IGF-1 Trade-Off: Perform…

The IGF-1 Trade-Off: Performance vs. Longevity

Rhonda Patrick5m · 2013-09-04

Claims Made

10

Claims Supported

9

Support Rate

90%

Support rate

9 of 10 claims supported

9 supported1 partial / not

Claims from this content

10

✓Well SupportedThe increase in growth hormone from sauna use is likely due to increased activity of hypothalamic neurons that regulate heat and stimulate growth hormone release.✓Well SupportedA common mutation involving the deletion of exon 3 in the growth hormone receptor is present in 3-4% of the general population and 12% of centenarians.✓Well SupportedDecreasing IGF-1 and growth hormone levels in mice, worms, and flies leads to a 50% extension in lifespan, while overexpressing them reduces lifespan by 50%.✓Well SupportedPolyphenols function as signaling molecules that activate the body's defenses against damage and aging.Partially Supported

More from Rhonda Patrick

Rhonda Patrick on Sauna Use

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Growth hormone and IGF-1 enhance performance by increasing lean muscle mass, decreasing adipose tissue, promoting neurogenesis, and providing neuroprotection.

◐Partially SupportedBoosting lean muscle mass and neurogenesis through strenuous exercise, and enhancing stress resistance gene expression via polyphenols and a balanced diet, are recommended for longevity and performance over caloric restriction.

◐Partially SupportedHormesis through exposure to substances like kakens and polyphenols can boost antioxidant gene expression and increase stress resistance without reducing growth hormone or IGF-1.

✕Not SupportedCaloric restriction to decrease growth hormone or IGF-1 levels can have downsides including stunted growth, reduced fertility, brain atrophy, muscle atrophy, and diminished sex drive.

◐Partially SupportedReducing IGF-1 expression increases stress resistance and can extend lifespan.

◐Partially SupportedGrowth hormone replacement therapy in elderly men increases lean muscle mass and decreases adipose tissue, and in adults with mild cognitive impairment boosts executive cognitive function and verbal memory.