Stop fearing cholesterol

PS

Paul Saladino16m · 2023-05-27

Claims Made

42

Claims Supported

22

Support Rate

52%

Support rate

22 of 42 claims supported

22 supported20 partial / not

Claims from this content

35

Not SupportedExcluding genome-wide association studies from analysis presents a different picture of LDL's role in cardiovascular health.Partially SupportedIncluding healthy saturated fats in the diet can increase HDL cholesterol and decrease triglycerides, while potentially increasing LDL cholesterol.Partially SupportedEthical medical practice requires transparent communication of absolute risks and benefits to patients.Partially SupportedLipoprotein(a) [LP(a)] is an LDL-like particle containing ApoB and Apo(a) moieties, with ApoB being a marker of atherogenic lipoproteins.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

In individuals with FH who develop heart disease, LDL levels do not differ from those who do not develop heart disease.

Partially SupportedThe cholesterol-lowering industry has a significant economic interest in promoting the fear of cholesterol.

Not SupportedSeed oils are a significant negative impact on health that people should focus on eliminating.

Partially SupportedLifestyle changes are powerful alternatives to medications for chronic disease management, likely improving lifespan and definitely improving quality of life.

Partially SupportedThe speaker is proactively trying to increase their LDL cholesterol by consuming more saturated fat to improve longevity.

Not SupportedFor individuals at low risk of heart disease, statins offer at best a 1% chance of preventing a non-fatal heart attack or stroke over five years, without side effects, and without prolonging life.

Partially SupportedIn individuals needing more saturated fat, LDL cholesterol may increase while triglycerides decrease and HDL cholesterol increases.

Partially SupportedIn the United States, at least 50 million people, possibly more, are taking statins.

Partially SupportedGood health ultimately comes from lifestyle, not from a medicine bottle.

Not SupportedThe presumption that LDL cholesterol should be lowered because genetically low cholesterol individuals do not develop heart disease is flawed.

Partially SupportedPhysicians often fail to check fasting insulin, which is crucial for understanding cardiovascular risk.

Not SupportedA systematic review suggests the hypothesis that lower cholesterol is better is flawed, with no correlation found between lower cholesterol and reduced heart attacks or strokes.

Partially SupportedMany individuals with familial hyperlipidemia do not develop atherosclerosis despite genetic predispositions.

Not SupportedPhysicians often focus excessively on the LDL number when interpreting lipid panels.

Partially SupportedGenetic polymorphisms associated with familial hyperlipidemia can affect immune cells and clotting or immunologic pathways involved in plaque formation.

Partially SupportedPatients should inquire about a drug's necessity, absolute benefits and harms, consequences of inaction, and safer alternatives.

Partially SupportedCholesterol may offer protection against infections like pneumonia in older individuals.

Partially SupportedThe optimal level of total cholesterol for longevity in adults is between 210-240 mg/dL.

Partially SupportedA paper suggests that high LDL is not associated with increased mortality in individuals over 60 years old.

Not SupportedSeed oils, especially when heated, produce toxic aldehydes which are carcinogenic and harmful to the heart and brain.

Not SupportedPowerful industries profit from flawed cholesterol science, influencing university research funding and perpetuating the narrative.

Partially SupportedLipid panels alone are insufficient for making clinical decisions about cardiovascular risk.

Not SupportedMendelian randomization studies are inherently flawed.

Partially SupportedThere is significant discordance in the longevity space regarding whether to lower or raise Apob/LDL cholesterol.

Partially SupportedThe benefit of altering a biomarker with drug therapy must be confirmed by double-blind randomized controlled trials to ensure patient benefit.

Partially SupportedHeart disease is a chronic inflammatory condition exacerbated by metabolic risk factors, with little to do with cholesterol itself.

Not SupportedA cardiologist proactively does not take any action to lower a patient's cholesterol, describing the current paradigm as 'Ford science' and flawed.

Not SupportedImproving cholesterol profiles by focusing on insulin resistance, HDL, and triglycerides is possible, but public health drives to lower total peripheral and LDL cholesterol for the majority are not advised.

Partially SupportedThe belief that cholesterol is bad is deeply ingrained, even among educated individuals.

Not SupportedThe focus on lowering cholesterol as the primary method for preventing heart disease has failed.

Partially SupportedIn individuals over 60, lower cholesterol levels are associated with increased mortality.