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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Does being in a ketogenic state affect NAD? — Whalespan

Content›Video›Does being in a ketogenic st…

Does being in a ketogenic state affect NAD?

Paul Saladino4m · 2022-01-23

Claims Made

10

Claims Supported

8

Support Rate

80%

Support rate

8 of 10 claims supported

8 supported2 partial / not

Claims from this content

10

✓Well SupportedTo activate longevity genes, the body needs to be tricked into thinking it is under threat of survival without causing damage.◐Partially SupportedKetones may improve ApoE4-related memory deficiency by activating sirtuins and altering the NAD+/NADH ratio.◐Partially SupportedA ketogenic diet may offer longevity benefits by activating similar pathways to other stress-response interventions.◐Partially SupportedBeta-hydroxybutyrate has epigenetic roles, acting as an HDAC1 inhibitor and potentially affecting Foxo3 and NAMPT.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Ketosis may increase NAD levels similarly to NMN and NR supplementation.

◐Partially SupportedA ketogenic diet in mice reduced PARP1 levels and DNA damage in the hippocampus within three days and increased NAD levels.

◐Partially SupportedKetones are relevant to the epigenome because histones can be butyrolated.

◐Partially SupportedA human study using magnetic resonance spectroscopy found that ketosis increases the NAD to NADH ratio in the healthy brain.

◐Partially SupportedKetones and NAD modulate the epigenome in response to dietary changes.

◐Partially SupportedKetosis may stimulate the same pathways as caloric restriction and exercise.