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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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How a longevity study is conducted with mice | Peter Attia & Rich Miller — Whalespan

Content›Video›How a longevity study is con…

How a longevity study is conducted with mice | Peter Attia & Rich Miller

Peter Attia19m · 2024-01-02

Claims Made

39

Claims Supported

35

Support Rate

90%

Support rate

35 of 39 claims supported

35 supported4 partial / not

Claims from this content

18

✓Well SupportedFemale mice may be more sensitive to rapamycin than male mice.✓Well SupportedMouse longevity studies typically use 100 male and 100 female controls per site per year, and 50 male and 50 female treated mice per drug per site.✓Well SupportedIn a five-drug trial within the ITP, there are 600 male and 600 female controls, and 1500 male and 1500 female mice receiving drugs.✓Well SupportedRapamycin is not stable at the gastric pH of mice, and the same appears to be true in humans.✓Well Supported

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Mice at the Michigan ITP site are approximately 10% lighter than mice at other sites.

◐Partially SupportedMeasuring mRNA in the liver of pilot mice helps confirm a drug has had a biological effect.

✕Not SupportedSelecting a test group based on observed best results leads to self-deception and false positives.

◐Partially SupportedStatistical analysis stratifies results by site when accounting for site-specific differences in male mouse survival, comparing controls to treated mice within each location.

◐Partially SupportedSGlt2 inhibitors increase median lifespan in male mice by 14% with a maximum extension of 9%, but have no effect on female mice.

◐Partially SupportedThe diabetes drug kagalen floen increased lifespan in males but not females.

◐Partially SupportedAn 80-day increase in median lifespan for mice, from 800 to 880 days, represents a 10% increase.

◐Partially SupportedMedian lifespan is the age at which 50% of a mouse population has died.

◐Partially SupportedFuture studies may investigate lower doses or shorter treatment durations for female mice with drugs like Kagolfloen to avoid potentially toxic high blood concentrations.

◐Partially SupportedProportional hazard is a primary statistical outcome in longevity studies, closely approximated by median lifespan.

◐Partially SupportedKagalen floen may be administered at a lower dose or stopped at middle age to mitigate toxicity in female mice.

◐Partially SupportedDrug formulations are tested by dissolving them in alcohol or incorporating them into corn oil suspensions to optimize delivery into food.

◐Partially SupportedMaximum lifespan in mice is not statistically useful due to high variability.

◐Partially SupportedCandidate drugs in longevity studies are typically administered via food, not intravenously or intramuscularly, due to the labor-intensive nature of injections and the need for a separate control group for sham injections.