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Rapamycin extends mouse lifespan 9–14%
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The role of dopamine in addiction | Anna Lembke and Peter Attia — Whalespan

Content›Video›The role of dopamine in addi…

The role of dopamine in addiction | Anna Lembke and Peter Attia

Peter Attia9m · 2024-10-15

Claims Made

13

Claims Supported

13

Support Rate

100%

Support rate

13 of 13 claims supported

13 supported0 partial / not

Claims from this content

8

◐Partially SupportedNematodes release dopamine in response to food, which aids locomotion towards it.◐Partially SupportedDopamine release in the reward circuitry increases during pleasurable or reinforcing activities.◐Partially SupportedDopamine acts as the final common pathway for all reinforcing substances and behaviors, leading to its release in the brain's reward circuitry.✓Well SupportedThe 'Addiction Economy' hijacks the reward system by spiking dopamine and reducing prefrontal cortex activity, leading to craving and reduced executive control.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

L-DOPA treatment for Parkinson's can lead to addictive disorders in about 25% of patients because it binds dopamine receptors in the reward pathway, with risk being dose-dependent.

◐Partially SupportedA robust prefrontal cortex is potentially protective against addiction.

◐Partially SupportedIndividuals with cognitive or attentional disorders have a higher risk of developing addictive disorders.

◐Partially SupportedParkinson's disease is characterized by dopamine depletion in the substantia nigra, treated with L-DOPA, a dopamine precursor that crosses the blood-brain barrier.