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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
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How seed oils affect macular degeneration — Whalespan

Content›Video›How seed oils affect macular…

How seed oils affect macular degeneration

Paul Saladino12m · 2023-06-07

Claims Made

21

Claims Supported

19

Support Rate

90%

Support rate

19 of 21 claims supported

19 supported2 partial / not

Claims from this content

17

✓Well SupportedVegetable oil consumption is associated with macular degeneration.✓Well SupportedA study found a correlation coefficient of 0.78 between average seed oil consumption over 25+ years and macular degeneration in 20 nations.✓Well SupportedLinoleic acid is susceptible to oxidative damage, leading to the formation of toxic breakdown products.◐Partially SupportedProcessed foods, in addition to vegetable oils, are implicated in the rise of macular degeneration.◐Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Advanced lipid oxidation end products include 4-HNE, malondialdehyde, carboxyethylpyrrole, and acrolein.

◐Partially SupportedThe number of people affected by AMD has increased from fewer than 50 cases in 1851-1930 to 196 million by 2020.

◐Partially SupportedCarboxyethylpyrol (CPE), a breakdown product of linoleic acid, is known to cause autoimmunity in some individuals.

◐Partially SupportedMacular degeneration involves the loss of retinal pigment epithelial cells, which support photoreceptors and are not regenerative.

◐Partially SupportedK2 deficiency is hypothesized to be an issue in AMD because Brook's membrane calcifies similarly to coronary arteries in heart disease.

◐Partially SupportedMacular degeneration involves loss of retinal pigment epithelial cells and thickening/calcification of Bruch's membrane, analogous to atherosclerotic plaque.

◐Partially SupportedMacular degeneration (AMD) was extremely rare before the 20th century, with fewer than 50 documented cases between 1851 and 1930.

◐Partially SupportedConsuming vegetable oils leads to breakdown products similar to how burning tobacco creates thousands of chemicals.

◐Partially SupportedDeficiencies in fat-soluble vitamins A, D, and K2 are drivers or hypothesized drivers of macular degeneration.

◐Partially SupportedThe macula is the central retina responsible for approximately 10 degrees of central vision.

◐Partially SupportedCarboxyl pyrol, a breakdown product of vegetable oils, can induce autoimmunity by forming antibodies that cross-react with retinal antigens.

◐Partially Supported14 million people worldwide had severe vision loss or blindness by 2006.

◐Partially SupportedConsuming vegetable oils can lead to hundreds of breakdown products.