The Peptide Lie: What Influencers Won’t Tell You

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Paul Saladino28m · 2026-04-11

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63

Claims Supported

28

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28 of 63 claims supported

28 supported35 partial / not

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Not SupportedIndividuals with cancer or high risk of cancer should avoid BPC 157 due to its pro-angiogenic effects.Well SupportedPaul Saladino has been over 90% carnivore, including organ meats daily, since a hunting trip.Well SupportedAn ideal body fat percentage for males is between 10% and 12%, and losing weight if too high can increase testosterone, but going too lean will decrease testosterone.Well SupportedPaul Saladino maintains a testosterone level of approximately 800 ng/dL without hormone therapy.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Some patients who discontinue GLP-1 agonists do not regain weight if they have implemented effective training and nutrition strategies.

Partially SupportedPeptides are small proteins composed of 2 to 50 amino acids, sometimes up to 75 or 100.

Not SupportedBPC-157 and TB-500 should not be used chronically for regeneration or healing from minor injuries; cycling may be considered for major injuries.

Not SupportedIllegally sourced peptides for research purposes can contain low-level lipopolysaccharides and may be counterfeit, posing health risks.

Partially SupportedCJC-1295 and Ipamorelin are growth hormone secretagogues.

Not SupportedMelanotan may increase the risk of melanoma.

Not SupportedUsing GLP-1 agonists for weight loss may lead to lifelong dependence and significant negative side effects.

Not SupportedMelanotan may increase the risk of melanoma.

Not SupportedGLP-1 receptor agonists carry potential negative side effects such as lean body mass loss and bone loss.

Partially SupportedAchieving longevity and a good quality of life requires consistent effort through diet and movement, and there are no shortcuts.

Well SupportedIndividuals should prioritize optimizing behaviors like nutrition and supplementation before considering TRT to address low testosterone.

Partially SupportedAchieving extreme leanness often leads to significantly suppressed hormone levels, impacting reproductive health and hormonal balance.

Well SupportedEating single-ingredient foods resets the body's response to food, making dietary choices easier and avoiding deprivation.

Partially SupportedMen who achieve very low body fat levels (below 8%) without exogenous testosterone will experience a significant drop in testosterone.

Partially SupportedPrioritizing eating real, unprocessed foods can lead to significant weight loss without the use of medications like GLP-1 agonists.

Partially SupportedFor obese individuals unable or unwilling to change their diet, GLP-1 medications may be a net positive intervention for long-term health and weight loss.

Partially SupportedSignificant weight loss can be achieved through disciplined adherence to diets like carnivore, animal-based, or simple single-ingredient foods, without relying on GLP-1 agonists.

Partially SupportedMelanotan is not FDA approved and is considered a gray market use.

Partially SupportedA sustainable approach to using GLP-1 agonists for weight loss prioritizes simple, unprocessed foods.

Partially SupportedWeight loss achieved through GLP-1 agonists can result in sarcopenia, characterized by significant loss of muscle mass, particularly in the gluteal region.

Partially SupportedA 2024 study found injectable semaglutide bought online had purity rates as low as 7%.

Not SupportedExcess growth hormone can lead to heart failure.

Partially SupportedMaintaining adequate testosterone levels is crucial for men to preserve libido, sexual function, and fertility as they age.

Partially SupportedBlocking angiogenesis is a strategy to inhibit cancer growth.

Not SupportedPeptides like Matsi are unnecessary as the body naturally produces these compounds through exercise.

Partially SupportedFor women, a healthy body fat range is 18% to 24%, with levels outside this range negatively affecting hormones.

Partially SupportedMen in bodybuilding shows and women in bikini competitions are generally not hormonally healthy and are often infertile.

Partially SupportedGLP-1 receptor agonists like semaglutide and tirzepatide, and triple agonists like retatrutide, are modified to last longer in the body than endogenous GLP-1, leading to reduced appetite and potential weight loss.

Partially SupportedMost exogenous peptides are administered via injection, with semaglutide being an exception formulated for oral delivery.

Partially SupportedAndre the Giant's death at age 46 from congestive heart failure, arthritis, chronic pain, and enlarged heart are presented as consequences of excessive growth hormone.

Partially SupportedMost bodybuilders use exogenous testosterone, implying significant muscle gain requires external hormonal support.

Not SupportedOver 40% of peptide products from online suppliers have incorrect dosages or contaminated ingredients, and up to 93% of injectable semaglutide purchased online was not actual semaglutide.

Not SupportedGLP-1 agonists cause a dose-dependent increase in heart rate with unknown long-term consequences.

Not SupportedWeight loss from semaglutide is not sustainable long-term without learning to eat simple, unprocessed foods.

Partially SupportedElite female athletes may maintain a body fat of 15-16% and retain menstrual cycles, but most women lose their period and fertility if they become too lean.

Partially SupportedThe rise in obesity rates is due to the consumption of ultra-processed foods, not genetic changes.

Not SupportedGLP-1 agonists negatively affect metabolism and muscle mass unless protein intake is strictly managed.

Not SupportedUsing GLP-1 agonists to achieve very low body fat levels can negatively impact sex hormones.

Partially SupportedBenefits from growth hormone secretagogues typically disappear within weeks of stopping the peptides.

Partially SupportedGrowth hormone is released by the pituitary gland in a pulsatile fashion.

Not SupportedExtreme calorie restriction to achieve very low body fat can decrease testosterone levels.

Partially SupportedGLP-1 is a naturally occurring peptide released after eating that signals satiety and lasts only a few minutes.

Partially SupportedThe body naturally produces numerous peptides, including insulin, ghrelin, GLP-1, GIP, BPC 157, oxytocin, and thymosin beta 4.

Not SupportedExcess growth hormone can lead to insulin resistance, metabolic health problems, and increased cancer rates.

Partially SupportedGrowth hormone secretagogues like CJC-1295 and epimelarin can mimic the body's natural pulsatile growth hormone secretion patterns.

Not SupportedFor men, insufficient sleep, extreme calorie restriction, excessive fasting, very low carbohydrate intake, or using drugs like retatrutide or semaglutide can lead to dangerously low testosterone levels.