Is Methylene Blue REALLY Worth The Hype?

PS

Paul Saladino17m · 2025-04-16

Claims Made

33

Claims Supported

9

Support Rate

27%

Support rate

9 of 33 claims supported

9 supported24 partial / not

Claims from this content

27

Not SupportedMethylene blue is not a beneficial intervention for improving mitochondrial function in individuals without a block in the mitochondrial electron transport chain.Well SupportedNose-to-tail nutrition, particularly desiccated organ supplements, is critical for reintroducing nutrients missing from modern diets.Not SupportedSeed oils, including corn, canola, safflower, sunflower, soybean, peanut, and grapeseed oils, should be avoided due to their linoleic acid content.Partially SupportedMethylene blue inhibits MAOA, increasing serotonin in the synaptic cleft.Not Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Evidence for metformin extending human lifespan is not convincing, and research is shifting towards rapamycin.

Not SupportedAvoiding seed oils is crucial for health because their linoleic acid content is prone to oxidation, creating oxidative stress.

Partially SupportedThe perceived benefits of methylene blue may stem from MAOA inhibition causing serotonergic changes, rather than actual mitochondrial improvement.

Partially SupportedSoybean oil, corn oil, and canola oil have significantly higher linoleic acid content than animal fats like tallow.

Partially SupportedMethylene blue at low concentrations can act as a metabolic enhancer, but at higher concentrations can be a metabolic poison.

Not SupportedMethylene blue is a strong MAOA inhibitor and can lead to serotonin syndrome if taken with other serotonergic compounds.

Partially SupportedMethylene blue can cause temporary blue discoloration of the tongue and brain.

Partially SupportedMethylene blue has shown underwhelming data in studies for Alzheimer's disease.

Partially SupportedCoenzyme Q (Ubiquinone) is synthesized in the body and found in significant amounts in muscle meat, particularly heart.

Not SupportedMethylene blue is not beneficial for most humans long-term and is likely overhyped.

Partially SupportedConsuming excessive amounts of seed oils creates an ATP leak in the body, impairing energy production and contributing to metabolic dysfunction.

Partially SupportedMetformin and berberine partially inhibit mitochondrial complex I.

Partially SupportedNiacin, riboflavin, co-enzyme Q10, and copper are essential nutrients for mitochondrial health.

Partially SupportedEliminating processed sugar and seed oils can improve mitochondrial health.

Partially SupportedMethylene blue treats methemoglobinemia by reducing iron in hemoglobin from the ferric (Fe3+) state back to the ferrous (Fe2+) state, which allows it to bind oxygen effectively.

Not SupportedProcessed sugar increases lipopolysaccharide (LPS) and polysaccharides, contributing to oxidative stress and metabolic dysfunction.

Not SupportedMethylene blue does not counteract seed oil toxicity.

Partially SupportedRotenone, metformin, and berberine can block complex 1 of the mitochondrial electron transport chain.

Not SupportedMethylene blue does not improve long-term mitochondrial health or function and may be harmful by decreasing ATP production.

Not SupportedBerberine is a partial toxin for complex I of the mitochondria.

Partially SupportedMany individuals taking methylene blue experience psychological changes due to monoamine oxidase A (MAO-A) inhibition, which they may mistakenly attribute to improved energy production or mitochondrial benefits.

Partially SupportedMeat, liver, egg yolks, and whole foods are good sources of essential mitochondrial nutrients like niacin, riboflavin, co-enzyme Q10, and copper.

Partially SupportedMethylene blue acts as a redox-reactive compound, moving electrons, which may relate to potential benefits in the electron transport chain.