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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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The Biology of Social Interactions & Emotions | Dr. Kay Tye — Whalespan

Content›Video›The Biology of Social Intera…

The Biology of Social Interactions & Emotions | Dr. Kay Tye

Andrew Huberman2h 31m · 2024-02-05

Claims Made

200

Claims Supported

156

Support Rate

78%

Support rate

156 of 200 claims supported

156 supported44 partial / not

Claims from this content

87

✓Well SupportedAG1 is a vitamin, mineral, probiotic drink with adaptogens designed to meet foundational nutritional needs and provide insurance for adequate fruit and vegetable intake.✓Well SupportedAndrew Huberman drinks Athletic Greens twice a day, typically once in the morning and again in the afternoon or late afternoon, mixed with water and lemon or lime juice.✓Well SupportedBody temperature must drop by 1-3 degrees Fahrenheit to fall and stay deeply asleep, and must increase by 1-3 degrees Fahrenheit to wake up refreshed.✓Well SupportedAG1 is recommended as the single supplement to take for supporting physical health, mental health, and cognitive and physical performance by covering foundational nutritional bases.

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓Well Supported

Andrew Huberman dissolves one packet of Element in 16-32 ounces of water upon waking and during exercise for hydration and electrolyte intake.

✓Well SupportedSmart mattress covers can be programmed to maintain a specific sleep temperature, which aids in falling asleep, achieving deep sleep, and REM sleep.

✓Well SupportedSupplements can provide benefits for enhancing sleep quality, improving focus, supporting hormones, and improving mental and physical health and performance.

✓Well SupportedAdequate intake of sodium, magnesium, and potassium is vital for cell function, especially nerve cells.

✓Well SupportedGut microbiota can influence brain function by producing neurochemicals like GABA, dopamine, and serotonin.

✓Well SupportedUsing a CGM and associated programs can help optimize food combinations, exercise, and sleep schedules for better blood glucose control and energy levels.

✓Well SupportedElectrolyte drinks with zero sugar and appropriate ratios of sodium, magnesium, and potassium can improve mental and physical functioning when well-hydrated.

✓Well SupportedRegulating light exposure is the strongest zeitgeber and should be addressed first to align sleep-wake cycles and exercise.

✓Well SupportedSupreme Court judges' rulings on parole decisions are more lenient after meal breaks, suggesting that judges' decisions are influenced by their hunger state.

✓Well SupportedMDMA can foster empathy, which can significantly benefit relationships.

✓Well SupportedThe directionality and intensity of light exposure significantly impacts mood-regulating mechanisms.

◐Partially SupportedPsychedelics may have important roles in clinical contexts, such as treating depression or trauma, when administered legally and safely under professional supervision.

◐Partially SupportedSocial homeostasis is the sense of experiencing an adequate amount of social interaction.

◐Partially SupportedThe social homeostasis model suggests that the body detects a deficit in social contact and activates effector systems to seek social interaction.

◐Partially SupportedThe amygdala's response to a stimulus decays quickly if the stimulus is not predictive of something important.

◐Partially SupportedPsychedelics are a powerful tool for changing brain circuitry through experience.

◐Partially SupportedPrefrontal cortical neurons can represent and decode which animal is dominant in food-deprived mice.

◐Partially SupportedIn mice, one day of food deprivation shifts neural pathways to prioritize food acquisition over fear responses.

◐Partially SupportedAmygdala neurons can exhibit synaptic strengthening when animals learn things and fire in response to cues that predict rewards.

◐Partially SupportedWaking up at 5:00 AM, regardless of bedtime, provides a strong antidepressant effect and increases productivity.

◐Partially SupportedHunger influences mood and decision-making, as shown by judges being less lenient when hungry.

◐Partially SupportedPsychedelic experiences may involve looser transitions between different brain states.

◐Partially SupportedReducing top-down inputs to the amygdala and creative processing regions is key for well-being.

◐Partially SupportedHuman data analysis remains valuable for neuroscience projects.

◐Partially SupportedMaternal separation in monkeys causes permanent damage, leading to failure to resocialize and health problems.

◐Partially SupportedModerate to low doses of psilocybin in animals can allow essential functions but may affect behavior in ambiguous situations.

◐Partially SupportedPsychedelics may increase lability between different emotional states.

◐Partially SupportedThe amygdala processes emotional valence, determining if information is assigned positive or negative significance.

◐Partially SupportedResearchers are studying the effects of social rank changes in animals by rehiring them into new groups.

◐Partially SupportedExperiential statistics, such as past experiences of abuse, scarcity, or abundance, shape how individuals interpret social interactions and form behaviors.

◐Partially SupportedThe amygdala performs a role in determining safety by assessing new environments, people, and potential threats largely unconsciously.

◐Partially SupportedPrefrontal cortical neuron firing patterns can predict competition winners regardless of trial outcome.

◐Partially SupportedResearch exploring psychedelics as therapy for various conditions is important and valuable.

◐Partially SupportedThe amygdala's bottom-up signals can be modulated by top-down processing from the prefrontal cortex.

◐Partially SupportedPsychedelics can make emotional states, including sadness, more labile, potentially leading to therapeutically beneficial intense experiences with support.

◐Partially SupportedChildren's brains exhibit robust neuroplasticity, making early life a critical period for developing healthy empathic attunement and theory of mind.

◐Partially SupportedChronic social isolation leads to negative social behaviors like territoriality, aggression, or avoidance.

◐Partially SupportedKay Tye limits social media and email use to less than one hour per week to maintain cognitive clarity.

◐Partially SupportedAn abundance mindset is beneficial, while a scarcity mindset is detrimental.

◐Partially SupportedThe amygdala is involved in assigning importance to stimuli but not in producing autonomic arousal.

◐Partially SupportedThe body adapts to a new baseline of social engagement, where a previously perceived deficit can become a new normal.

◐Partially SupportedWaking up late can lead to sleep deprivation if one also wakes up early, and results in missing early morning sunrise and activities like surfing.

◐Partially SupportedSkills such as regulating one's own emotions and engaging with others in a healthy, sustainable way are crucial and will be needed throughout life, potentially more so than academic subjects that are often forgotten and need relearning.

◐Partially SupportedTaking agency over designing one's lifestyle to be ideal is very important for overall well-being.

◐Partially SupportedLimiting digital input allows the brain to be clear, creative, and receptive to new ideas.

◐Partially SupportedThe amygdala complex assigns importance to stimuli but is not responsible for producing autonomic arousal associated with panic or fear.

◐Partially SupportedHallucinations may be explained by changes in the signal-to-noise ratio in neurons, leading to pattern completion of noise and reinterpretation of neural maps.

◐Partially SupportedThe amygdala responds to any stimulus that is important, regardless of whether it is positive or negative.

◐Partially SupportedSet and setting, individual variability, and predictive biomarkers may explain unpredictable outcomes of psychedelic therapies.

◐Partially SupportedEngaging a neural pathway strengthens it, potentially increasing associated emotions.

◐Partially SupportedMost people, when not on psychedelics, avoid uncomfortable emotions.

◐Partially SupportedPsychedelic therapy outcomes may be influenced by set, setting, individual variability, or predictive biomarkers.

✕Not SupportedSocial media interactions are unlikely to provide a satiating social connection and may create more hunger for social interaction rather than satisfying it.

◐Partially SupportedThe amygdala is involved in processing emotions beyond fear.

◐Partially SupportedLimiting incoming information, such as emails and social media, is beneficial for creative processing and overall brain function.

◐Partially SupportedThe amygdala is involved in reinforcing positive behaviors and experiences.

◐Partially SupportedThe brain's priority list can invert during starvation, prioritizing food acquisition over fear and safety.

◐Partially SupportedNeurons in the brain encode loneliness, which is the absence of social contact.

◐Partially SupportedAmygdala projections can encode either reward or fear.

◐Partially SupportedPsychedelics can induce life-changing epiphanies that lead to lasting changes in life habits, differentiating them from most other therapeutic treatments.

◐Partially SupportedPsychedelics offer a unique ability to experience and recall altered brain states, which is difficult to achieve with REM sleep or psychotic breaks.

◐Partially SupportedThe amygdala receives information from the body, including hunger signals via gin receptors.

◐Partially SupportedYoungest siblings tend to break socio-cultural norms more than older siblings and may take on more risks.

◐Partially SupportedMorning exercise routines positively influence the rest of the day.

◐Partially SupportedSocial media use may trigger the amygdala and cloud productive neural circuit activation.

◐Partially SupportedViewing someone as a competitor or adversary is inversely correlated with empathy.

?Limited ResearchHarmful health consequences of social isolation may stem from initial detection of social deficit or subsequent adaptation to a new social set point.

◐Partially SupportedSocial interactions have neurochemical, neurocircuit, and hormonal aspects that influence how they make us feel.

◐Partially SupportedDopamine neurons in the dorsal raphe nucleus, when stimulated, cause animals to move away from the area and exhibit aversion, unlike VTA dopamine neurons.

◐Partially SupportedDelegating email management and being selective about emails can prevent overwhelm and stress.

◐Partially SupportedCurrent research focuses on understanding hallucinations at a quantitative, mathematical level, including cellular mechanisms and signal-to-noise ratio.

◐Partially SupportedSocial media can provide valuable feedback and help develop a 'theory of mind'.

◐Partially SupportedAnonymous feedback, such as teaching evaluations or lab surveys, is valuable for improvement.

◐Partially SupportedConsciously creating dynamic social experiences and protecting alone time enhances social homeostatic system elasticity, flexibility, and resilience.

◐Partially SupportedLoneliness is detrimental to health, and extroverts gain energy from social interactions while introverts reset through solo or one-on-one time.

◐Partially SupportedExperiencing impostor syndrome for approximately 20 years of a career can lead to constant self-doubt and questioning of one's abilities.

◐Partially SupportedAn optimal amount of social contact balances quantity and quality.

◐Partially SupportedSocial flexibility, the ability to be comfortable both alone and in large groups, is a key aspect of mental well-being.

◐Partially SupportedHaving multiple hobbies and non-work activities can make individuals better scientists.

◐Partially SupportedVoice calls provide more interbrain synchrony than text messages.

◐Partially SupportedSeasonal Affective Disorder (SAD) is a real phenomenon.

◐Partially SupportedSurfing provides exercise, cold exposure, photon exposure, and can be meditative and social.

◐Partially SupportedSocial isolation and perceived loneliness are associated with shortened lifespan and increased morbidity and mortality from diseases like cancer and heart disease.