What REALLY Causes HEART DISEASE?

Well SupportedMetabolic dysfunction, specifically insulin resistance, is the primary event leading to atherosclerosis, not LDL directly injuring the endothelium.

Well SupportedWhen Framingham data is not stratified by metrics associated with insulin resistance, LDL cholesterol shows a linear correlation with cardiovascular disease incidence.

Partially SupportedHypertension and low HDL are indicators of insulin resistance, a primary risk factor for cardiovascular disease.

Partially SupportedIf the endothelium and arteries are healthy, LDL becomes irrelevant to cardiovascular disease risk.