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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Can exercise replace alcohol cravings? — Whalespan

Content›Video›Can exercise replace alcohol…

Can exercise replace alcohol cravings?

Rhonda Patrick7m · 2022-11-02

Claims Made

12

Claims Supported

12

Support Rate

100%

Support rate

12 of 12 claims supported

12 supported0 partial / not

Claims from this content

9

✓Well SupportedFGF21, released during exercise, can cross the blood-brain barrier and bind to hypothalamic receptors, altering dopamine signaling.◐Partially SupportedExercise interventions have been shown to reduce alcohol consumption in individuals with alcohol abuse disorder compared to standard treatments.◐Partially SupportedAdministering FGF21 to non-human primates reduced alcohol consumption by 50%.◐Partially SupportedGiving FGF21 reduced alcohol consumption by up to 50% in mice and monkeys.◐Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Vigorous exercise offers enormous benefits for the brain and behavior.

◐Partially SupportedVigorous exercise, particularly aerobic exercise, can increase fibroblast growth factor 21 (FGF21) levels.

◐Partially SupportedExercise can be a useful adjunctive tool to combat alcohol abuse disorders.

◐Partially SupportedIncreased blood levels of FGF21 are observed after acute exercise, long-term fasting, very low calorie diets, excessive carbohydrate intake, and alcohol consumption.

◐Partially SupportedFGF21 regulates metabolism, including glucose uptake, insulin sensitivity, blood lipid cholesterol levels, and body weight.