How Seed Oils Are The Main Driver Of Disease with Chris Knobbeith

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Paul Saladino1h 24m · 2023-06-06

Claims Made

143

Claims Supported

134

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Support rate

134 of 143 claims supported

134 supported9 partial / not

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116

Well SupportedExcessive intake of linoleic acid arises from its concentration and abundance in processed seed oils.Well SupportedIndigenous populations studied typically consume diets where linoleic acid constitutes about 2% of fat intake, contrasting with 7-15% in Western diets.Well SupportedPork fat from pigs fed corn and soy can contain 10-15% or more linoleic acid, compared to wild pigs with around 4-5%.Well SupportedEggs from chickens fed corn and soy may be less healthy due to accumulation of linoleic acid.Well Supported

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Seed oils are included in baby formulas to match the linoleic acid content of human breast milk.

Well SupportedOxidized linoleic acid in cardiolipin creates leaky pores in the inner mitochondrial membrane, hindering ATP synthesis.

Well SupportedThe amount of acrolein in a large order of In-N-Out French fries on a Tuesday afternoon is equivalent to a pack of cigarettes.

Well SupportedLinoleic acid intake should ideally be kept below five grams per day, and potentially even below four grams per day.

Well SupportedIncreased consumption of chicken contributes to increased vegetable oil intake due to corn-based poultry feed.

Well SupportedThere is a temporal association between increased seed oil consumption and rises in obesity, asthma, diabetes, and chronic illness.

Well SupportedMinimizing or eliminating seed oils from the diet improves overall health and can positively impact various bodily functions.

Well SupportedVegetable oil consumption, particularly polyunsaturated fats like linoleic acid (omega-6), has increased dramatically in developed countries.

Well SupportedHunter-gatherer breast milk contains significantly lower amounts of linoleic acid (2-3% of calories) compared to westernized women's breast milk (10-15% of calories).

Well SupportedHumans cannot easily eliminate polyunsaturated fatty acids like linoleic acid, leading to their accumulation in the body.

Well SupportedReducing linoleic acid intake is predicted to be the most significant health improvement.

Well SupportedFruit may be acceptable for humans within an animal-based diet.

Well SupportedOmega-6 linoleic acid intake increased to approximately 18 grams per day by 1999 and 29 grams per day by 2008 in the US.

Well SupportedTallow is a preferred cooking fat for potatoes over seed oils, despite concerns about oxalates and lectins in potatoes.

Well SupportedThe oxidation of linoleic acid in LDL is the first step required to initiate cardiovascular disease.

Well SupportedDietary polyunsaturated fats, specifically omega-6 linoleic acid, accumulate in human cell membranes.

Well SupportedA study found a correlation coefficient of 0.78 between average seed oil consumption over 25+ years and macular degeneration in 20 nations.

Well SupportedMaternal linoleic acid intake is strongly correlated with childhood obesity.

Well SupportedHuman adipose tissue in studies from the 1960s contained approximately 7-8% stearic acid, while modern adipose tissue contains less than 3.5%.

Well SupportedLinoleic acid's polyunsaturated nature increases oxidative stress and can lead to mitochondrial shutdown.

Well SupportedEliminating seed oils may lead to significant health improvements, including better metabolic markers.

Well SupportedHeated vegetable oils, especially in fast food, can break down to form acrolein.

Well SupportedThere is a consistent correlation between linoleic acid consumption and macular degeneration in observational studies.

Well SupportedVegetable seed oil consumption in Japan increased four and a half fold from 9 grams per day in 1961 to 39 grams per day by 2004.

Well SupportedThe strong correlation between seed oil consumption and macular degeneration supports a compelling hypothesis.

Well SupportedDeclining sugar consumption alongside increasing chronic diseases suggests seed oils may be a primary driver.

Well SupportedThe quantity of fat and DHA in breast milk is directly correlated with the amount of fat consumed by the mother.

Well SupportedWestern diets have an omega-6 to omega-3 ratio of 7:1 to 12:1, while the Maasai diet has a ratio of 1.7.

Well SupportedExcess polyunsaturated fats, specifically linoleic acid, accumulate in the body and take over two years to eliminate.

Well SupportedIn 1865, ancestral linoleic acid (omega-6) intake was less than 1% of calories, approximately 2.2 grams per day.

Not SupportedRefined, bleached, deodorized, and heated seed oils are likely harmful to humans.

Partially SupportedSeed oils are a major driver of chronic illness.

Partially SupportedDietary intake of omega-6 linoleic acid approximately doubles in body fat over a three-year period, though this is a rough estimate with potential threshold effects.

Partially SupportedAdvanced lipid oxidation end products include 4-HNE, malondialdehyde, carboxyethylpyrrole, and acrolein.

Partially SupportedHumans have evolutionarily encountered very low amounts of polyunsaturated fatty acids (PUFAs) in their diet, unlike domesticated animals.

Partially SupportedA large serving of french fries cooked in prolonged heated oil can contain 1 to 1.5 milligrams of acrylene.

Partially SupportedAn animal-based diet including meat and organs, and potentially desiccated organ supplements, has been helpful for individuals with metabolic issues and allergies.

Partially SupportedJapan saw a 4.5-fold increase in vegetable oil consumption over 40 years, and China saw an 8-fold increase between 1963 and 2003.

Partially SupportedProcessed foods are likely a major driver of chronic illness, but the term needs definition.

Partially SupportedInforming restaurants about food sensitivities to seed oils and MSG can lead them to cook food in butter.

Partially SupportedThe number of people affected by AMD has increased from fewer than 50 cases in 1851-1930 to 196 million by 2020.

Partially SupportedBetween 1958 and 1999 in Japan, carbohydrate consumption decreased while fat consumption increased fourfold, yet health issues worsened.

Partially SupportedProcessed foods containing seed oils and refined wheat are the primary problems associated with sugar consumption, rather than sugar itself.

Partially SupportedLinoleic acid is unstable due to its multiple double bonds, making it prone to oxidation.

Partially SupportedEliminating processed food is the primary recommendation for improving health on a standard Western diet.

Partially SupportedInfant formula is the single most processed food on the planet, often replacing natural animal fats with vegetable oils.

Partially SupportedHeart and Soil Supplements uses grass-fed, grass-finished, regeneratively raised animals from New Zealand for their products, which are freeze-dried and encapsulated.

Partially SupportedSeed oils like canola and soybean oil are detrimental to health.

Partially SupportedProcessed foods, in addition to vegetable oils, are implicated in the rise of macular degeneration.

Partially SupportedMeat and organ meats improve testosterone levels, and testicles contain bioactive androgens including testosterone.

Partially SupportedMacular degeneration involves loss of retinal pigment epithelial cells and thickening/calcification of Bruch's membrane, analogous to atherosclerotic plaque.

Partially SupportedAge-related macular degeneration prevalence correlates strongly with average daily polyunsaturated oil consumption.

Partially SupportedProcessed sugar, wheat, and vegetable oils are primary drivers of chronic diseases like macular degeneration.

Partially SupportedOils from french fries can deposit in body fat and take three years to turn over.

Partially SupportedK2 deficiency is hypothesized to be an issue in AMD because Brook's membrane calcifies similarly to coronary arteries in heart disease.

Partially SupportedConsuming heated vegetable oils, particularly in fast food, is considered more dangerous than smoking cigarettes due to the accumulation of oils and the resulting pro-oxidated, pro-inflammatory environment.

Partially SupportedControlled interventional studies on linoleic acid in humans have not been adequately performed in the last 50-60 years.

Partially SupportedMacular degeneration was likely rare before the introduction of processed foods.

Partially SupportedObesity in infants and toddlers is likely caused by early consumption of formula made from vegetable oils, sugar, and refined flours.

Partially SupportedOmega-6 fatty acid intake increased significantly in Japan with increased seed oil consumption.

Partially SupportedKey ingredients in processed foods that may drive harm include sugar, seed oils, refined grains, flours, preservatives, glyphosate, and gums.

Well SupportedAbnormalities in cardiolipin and protein structures within mitochondria impair the electron transport chain and reduce ATP production.

Partially SupportedSeed oils include corn, canola, sunflower, safflower, soybean, and grape seed oils.

Partially SupportedSeed oils like canola and soybean oil were not present in significant amounts in ancestral diets and are now used in processed foods as cheaper preservatives, contributing to inflammation.

Partially SupportedAnimal studies show higher linoleic acid intake is linked to LDL oxidation, cancer, and cardiovascular disease.

Partially SupportedThe correlation between increased omega-6 from seed oils and increasing chronic illnesses is concerning.

Partially SupportedThe enzyme 15-lipoxygenase is involved in forming oxylams from linoleic acid, which may play a problematic role in atherogenesis.

Partially SupportedCarboxyethylpyrol (CPE), a breakdown product of linoleic acid, is known to cause autoimmunity in some individuals.

Partially SupportedAge-related macular degeneration is the leading cause of irreversible blindness in adults over 50 worldwide.

Partially SupportedDeficiencies in fat-soluble vitamins A, D, and K2 are hypothesized drivers of macular degeneration.

Partially SupportedChina has had low sugar consumption, averaging 60-80 calories per day, since the 1980s.

Partially SupportedModern medical education primarily teaches that smoking, drinking, and lack of exercise are the main health risks, neglecting diet.

Partially SupportedEggs from Angel Acres farm, fed non-corn/soy diets and pastured, contain approximately 0.17 grams of linoleic acid per egg.

Partially SupportedWhole Package from Heart and Soil supplements may improve depression, anxiety, panic attacks, night sweats, lack of energy, and inability to gain weight in males with severely low testosterone.

Partially SupportedA diet with omega-6 fatty acids above 4.4% is required to reliably produce cancer in laboratory animals.

Partially SupportedCarboxyethylpyrrole (CEP) can induce autoimmunity via sap-related antibodies that cross-react with retinal antigens, potentially contributing to macular degeneration.

Partially SupportedImpaired mitochondrial function causes cellular energy failure, preventing fat burning and leading to lipid droplet accumulation.

Partially SupportedCardiolipin is essential for maintaining proton charge in the inner mitochondrial membrane for ATP energy production.

Partially SupportedCardiolipin, found in inner mitochondrial membranes, contains four acyl tails often derived from linoleic acid in the heart.

Partially SupportedMcDonald's french fries are cooked in corn, canola, soybean, and partially hydrogenated soybean oil.

Partially SupportedCancer incidence in China increased 3.2-fold from 495 to 100,000 in 1991 to 1587 per 100,000 by 2017.

Partially SupportedCountries with no seed oil consumption show no correlation between smoking and lung cancer.

Partially SupportedCombined overweight and obesity rates in China increased from 15.3% in 1991 to 42% by around 2014.

Partially SupportedHigh consumption of vegetable oils, rather than sugar, is the primary driver of age-related macular degeneration across 25 nations.

Partially SupportedLinoleic acid can react with radicals to form advanced lipid oxidation products (ALOPs), including carboxy ethylpyrol (CPE).

Partially SupportedAn ancestrally appropriate diet, avoidance of vegetable oils, and high nutrient intake protect against cancer.

Partially SupportedPacific Islanders who smoke heavily do not show evidence of COPD or lung cancer.

Partially SupportedLung cancer incidence in China increased 465% while smoking prevalence decreased from 27% to 20%.

Partially SupportedCardiovascular disease in China increased 15-fold between 1990 and 2017.

Partially SupportedIn China, sugar consumption has declined while diseases and vegetable oil consumption have increased.

Partially SupportedMany products labeled healthy, vegan, or plant-based contain seed oils.

Partially SupportedOxidation is the primary harm from smoking, resolving about six months after cessation.

Partially SupportedAcrolein, a toxicant found in cigarette smoke, is considered the most carcinogenic and toxic part of a cigarette.

Partially SupportedThe incubation period for chronic diseases like cardiovascular disease, stroke, cancers, and macular degeneration can be four decades or longer.

Partially SupportedIn Japan, sugar consumption decreased from ~329 calories in 1989 to 283 calories in 2004, while saturated fat intake remained low at 7%.

Partially SupportedThe hypothesis that processed foods, sugars, and vegetable oils are the primary cause of chronic disease was understood by Western Price's research.

Partially SupportedHigh omega-6 diets may cause lipid droplet accumulation in the liver, retina, and brain by impairing mitochondrial function.

Partially SupportedCarboxy methylpyrol is a breakdown product of linoleic acid.

Not SupportedLong-term randomized controlled clinical trials for diet interventions are extraordinarily expensive, often last only a few weeks, and are difficult to control due to numerous confounders.

Partially SupportedThere were fewer than 50 reported cases of macular degeneration in the world's literature between 1851 and 1930.

Partially SupportedAll Westernized countries have an omega-6 intake above the 4.4% threshold, which is concerning for cancer and cardiovascular disease connections.

Partially SupportedResearchers must administer a carcinogen or irradiate animals and increase their dietary omega-6 intake above 4.4% to reliably induce cancer in animal studies.

Partially SupportedCoronary heart disease, Alzheimer's disease, macular degeneration, dementia, and obesity were virtually unknown in the 19th century.

Not SupportedCorn, canola, sunflower, safflower, and soybean oils are considered detrimental.

Not SupportedOlive oil and avocado oil have approximately 15% linoleic acid, making them less preferable than tallow and butter which contain 1-2% linoleic acid.

Partially SupportedFat-soluble vitamin deficiencies and Brook's membrane calcification can cause dry AMD by damaging the retinal pigment epithelium.

Partially SupportedInfant cardiolipin may differ from adult cardiolipin in westernized populations, potentially becoming enriched in linoleic acid with age and high linoleic acid diets.

Partially SupportedHigh omega-6 diets can lead to congestive heart failure in animals within three weeks.

Partially SupportedLinoleic acid is harmful.

Partially SupportedIncreased seed oil consumption in Japan correlated with doubled obesity rates, increased rates of breast cancer, other cancers, diabetes, and macular degeneration.

Partially SupportedProcessed foods like cakes, cookies, candies, and crackers are typically found outside the perimeter of a grocery store, while whole foods like fruits, vegetables, and meats are not.

Partially SupportedCracking and breaking of Brook's membrane allows vessels to grow underneath the retina, leading to bleeding and wet AMD, which causes vision loss.