Single dose of creatine improves cognitive performance and induces changes in cerebral high-energy phosphates during sleep deprivation

Single-dose creatine measurably affects cognition during 21h sleep deprivation — small N but tight design.

• 01Design: Randomized crossover trial — weighted accordingly in our rubric.
• 02Solid design; some limitations on generalizability or duration.
• 03Effect direction is consistent with adjacent literature in our index.

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