Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Glucose-handling side effects are dose-dependent and partially decoupled from the longevity mechanism.

• 01Design: Mechanistic — weighted accordingly in our rubric.
• 02Solid design; some limitations on generalizability or duration.
• 03Effect direction is consistent with adjacent literature in our index.

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