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The effect size is large enough to matter clinically, not just statistically.
The intervention improves the primary outcome at standard doses in healthy adults.
Benefits hold across the populations where it's been tested.
The effect size is large enough to matter clinically, not just statistically.
Mechanistic and trial evidence converge on a real, replicable effect.
Animal-model results don't translate to the human protocol being recommended.
The headline effect shrinks once you account for trial quality.
Animal-model results don't translate to the human protocol being recommended.
Confounding and publication bias inflate the apparent benefit.
Confounding and publication bias inflate the apparent benefit.