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Benefits hold across the populations where it's been tested.
Benefits hold across the populations where it's been tested.
The effect size is large enough to matter clinically, not just statistically.
The intervention improves the primary outcome at standard doses in healthy adults.
Mechanistic and trial evidence converge on a real, replicable effect.
Animal-model results don't translate to the human protocol being recommended.
Animal-model results don't translate to the human protocol being recommended.
Confounding and publication bias inflate the apparent benefit.
Animal-model results don't translate to the human protocol being recommended.
Confounding and publication bias inflate the apparent benefit.