Alpha-ketoglutarate is a central metabolite in the TCA and Krebs cycles that declines with age and may be beneficial when supplemented.

“it's a the TCA cycle and KB cycle central metabolite involved in hundreds of reactions it's a lot like NAD and they're doing different things but they're both central metabolites they're both going down with aging in organisms y and the idea is supplementing them back up would be beneficial.”

“So it's you're adding two metabolites that are both going down with aging that are both involved in hundreds of different they're giving you cellular metabolic flexibility. I think that's what they're doing. I don't think it's one pathway they're activating.”

“It's yeah it is it's a the TCA cycle or KB cycle central metabolite involved in hundreds of reactions. It's a lot like NAD. Y they're doing different things but they're both central metabolites. They're both going down with aging in organisms. Y and the idea is supplementing them back up would be beneficial.”