David Sinclair
Harvard genetics professor · Lifespan author.
Should I take creatine?
Yes, for almost everyone. 5g monohydrate daily, no loading phase needed.
Should I take rapamycin?
For healthy adults at standard weekly doses: Partially Supported. For those with kidney issues or active infection: not without a physician.
Should I take NAD+ supplements or IV NAD+?
Ignore IV NAD+. NMN/NR oral supplements: Watch.
Should I do 16:8 time-restricted eating?
For most people the calorie effect is the active ingredient. The metabolic-magic claims have not replicated.
Creatine improves cardiovascular health markers and reduces all-cause mortality risk.
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
Bryan Johnson's Blueprint rapamycin protocol extrapolates from mouse dosing to humans without trial data and is not safe to copy.
Chronic rapamycin meaningfully increases infection risk in immune-naive healthy adults.
Rapamycin slows wound healing enough to recommend pausing it around elective surgery.
Paste the URL — video, podcast, article, or paper — and we'll extract every claim and grade it against the literature.
Audit a URL →Native comments, Twitter mentions, and Reddit threads about David — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.