Paul Saladino· MD
what we know is that incorporation of a proteometic amino acid into proteins is a random process and although no specific proteins are targeted aggregation prone or intrinsically disordered proteins such as alpha synuclein or tau protein could be more sensitive to amino acid substitution those are proteins involved in neurodegenerative disorders if you go further in this paper what you will see is that in patients who have been given l-dopa for parkinsonism we find the presence of l-dopa incorporated into proteins it's very clear l-dopa might accelerate the progression of parkinson's proteins containing incorporated l-dopa are present in the blood and brain extracts from l-dopa-related excuse me l-dopa-treated individuals when present in proteins or other polymers l-dopa is one of nature's most effective adhesives and cross-linking agents and is a is capable of generating protein aggregates in cells preventing their removal by proteolysis