Peter Attia· MD
a four increases risk a little bit a three is neutral and a two actually is protective
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
a four increases risk a little bit a three is neutral and a two actually is protective
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ApoE4 might have been wonderful in during the Ice Age but now it's bad because it's associated with higher LDL It's associated with a more pro-inflammatory state and it's associated with more heart disease
the APO E4 Gene people who have two copies of the four are at significantly higher risk for Alzheimer's disease about 10 times higher risk
I found out that I have one ApoE4 allele. And of course, at that point, I became terrified of Alzheimer's because it increases the risk for Alzheimer's by two-fold and I'm writing an academic paper on this right now and getting into all the mechanisms--diet, lifestyle, things like that.
approximately 25% of the population have a specific form of apoe called apoe4 which is associated with higher circulating levels of LDL and also is associated with a two to threefold increased risk for Alzheimer's disease