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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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How to Personalize Your Nutrition Based On Genetics (Revised 3/19/15) — Whalespan

Content›Video›How to Personalize Your Nutr…

How to Personalize Your Nutrition Based On Genetics (Revised 3/19/15)

Rhonda Patrick12m · 2015-03-19

Claims Made

24

Claims Supported

15

Support Rate

63%

Support rate

15 of 24 claims supported

15 supported9 partial / not

Claims from this content

21

✓Well SupportedMeasuring vitamin D blood levels is crucial when supplementing, especially for individuals with polymorphisms affecting vitamin D conversion.✓Well SupportedThe conversion of ALA to EPA and DHA is inefficient, especially in post-menopausal women and individuals with certain gene polymorphisms.✓Well SupportedTwins with higher vitamin D levels have longer telomeres, corresponding to a five-year difference in biological aging.✓Well SupportedThe longevity gene FOXO3 is associated with increased lifespan in model organisms and a higher chance of becoming a centenarian in humans.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

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The APOE4 polymorphism is associated with higher LDL levels and a two to threefold increased risk for Alzheimer's disease.

✓Well SupportedThe conversion of beta-carotene to retinoic acid is poor and influenced by genetic polymorphisms like BCMO1.

✓Well SupportedFOXO3 promotes longevity by activating genes involved in stress resilience, antioxidant defense, DNA repair, tumor cell killing, and preventing protein aggregation.

◐Partially SupportedKnowing gene polymorphisms through tools like 23andMe and Promethease allows for tailored diet and lifestyle adjustments to potentially extend lifespan.

◐Partially SupportedWomen with the PEMT gene polymorphism impairing choline synthesis should increase dietary choline intake, with egg yolks being a good source.

✓Well SupportedSupplementing with 5-methyltetrahydrofolate and methylcobalamin (Vitamin B12) can lower homocysteine levels in individuals with MTHFR gene polymorphisms.

◐Partially SupportedGene polymorphisms are variations in DNA sequence that alter gene function and are thought to have been selected for.

◐Partially SupportedNutrigenomics is the study of how specific nutrients interact with an individual's genes, affecting metabolism and aging.

◐Partially SupportedMTHFR gene polymorphisms impair the conversion of folate to 5-methylfolate, which is crucial for gene regulation and homocysteine reconversion.

◐Partially SupportedIndividuals with a specific FUTC2 gene polymorphism may need to take sublingual vitamin B12 for adequate absorption.

◐Partially SupportedApproximately 40% of the population has a 40% reduced MTHFR enzyme efficiency, 20% has a 70% reduction, and 10% has an 80-90% reduction due to MTHFR gene polymorphisms.

◐Partially SupportedMTHFR gene polymorphisms are associated with higher homocysteine levels, which are linked to vascular diseases.

◐Partially SupportedHaving one copy of a gene polymorphism may or may not have a measurable effect, while having two copies does.

◐Partially SupportedGene polymorphisms in the BCMO1 gene can reduce the conversion of beta-carotene to retinal by 30-70%.

◐Partially SupportedPolymorphisms in the CYP2R1 gene can lead to lower circulating 25-hydroxy vitamin D levels and reduced enzymatic activity, potentially increasing all-cause mortality.

◐Partially SupportedGene polymorphisms can influence predispositions to diseases and determine phenotypes.

◐Partially SupportedApproximately 46% of the population has an NPF3 gene polymorphism leading to slightly lower vitamin B6 levels.