MTHFR gene polymorphisms impair the conversion of folate to 5-methylfolate, which is crucial for gene regulation and homocysteine reconversion.

“this specific cluster of polymorphisms are associated with the gene 510 methylene tetr Hydro folate reductase also known as MTHFR and is associated with the reduced capacity to convert 510 methylene Tetra hydrolate into five methylfolate five methyl folate plays a very important role for making those methyl groups that turn genes off and turn genes on in addition it also reconverts homosysteine into the amino acid methionine this means that while people with these Gene polymorphisms are able to make the DNA nucleotide thymine they aren't able to efficiently convert dietary folate or supplemental folic acid into five methyl folate”