The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
That's one that can. Yeah, I mean, FOXO3 is, in fact, if you go back to the worm studies I was talking about, that was one of the first things when you see it with your own eyes. You can take these worms that, you basically decrease their insulin signaling pathway and their IGF-1.
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there are individuals out there that have either additional copies of FOXO3 or who have versions of FOXO3 that are hyperactive, so to speak, those people tend to be 2.7 times more likely to live to 100 years of age or longer.
Those people tend to be 2.7 times more likely to live to 100 years of age or longer.
Fox o3 is one of these mutations that people might have heard Rhonda Patrick talked about a lot there are polymorphisms and Fox o3 that are associated with longevity and it's probably one of the most well studied ones
foxo3 is one of these mutations that people might have heard rhonda patrick talk about a lot there are polymorphisms than foxo3 that are associated with longevity and it's probably one of the most well studied ones
then 22% of our centenarians have mutation in FOXO 3a that's a common mutation in centenarians
so they'll say oh you have a favorable fox o3a genotype
he probably had 2 copies of the foxo3 polymorphism associated with longevity. Makes you resistant to stresses like smoking.
foxo3 is associated with longevity for several reasons flies and worms that have an equivalent of foxo3 or the homologue have a 100% increase in lifespan so worms go from living 15 days to 30 days mice that have the equivalent of foxo3 experience a 30% increase in lifespan and humans that have polymorphisms associated with making more fox03 have an increased chance of living to be 100 or being a centenarian
well those people that have that are able to deal with all sorts of damage so much better because they can just repair it constantly well those people are 2.7 times more likely to become a centenarian to live to be 100 which is pretty uh impressive