Paul Saladino· MD
and i love that you brought up the conversion of beta-carotene which many people call pre-vitamin a to retinoic acid which is the bio-available form of vitamin a that the polymorphism is in bcmo
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and i love that you brought up the conversion of beta-carotene which many people call pre-vitamin a to retinoic acid which is the bio-available form of vitamin a that the polymorphism is in bcmo
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there is a common mutation there's common polymorphism and human genetics in the bcmo gene which results in only a fraction of the population perhaps 60 to 70 percent of the population being able to convert beta-carotene to retinoic acid in any reasonable amount so that means 30 to 40 of the population can't really even do that conversion
people that have this these cluster of gene polymorphisms in the bcm1 gene can increase their dietary intake of animal products which are high in vitamin A or can supplement with the active form of vitamin A not beta carotene but be careful not to take too much vitamin A as it can be toxic at high doses