Rhonda Patrick· PhD
Compared with placebo, vitamin D supplementation resulted in LTL that was approximately 0.14 kilobase pairs higher over 4 years.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Compared with placebo, vitamin D supplementation resulted in LTL that was approximately 0.14 kilobase pairs higher over 4 years.
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Maintaining serum vitamin D levels of 40–60 ng/mL through daily supplementation is a reliable, evidence-based strategy to slow telomere shortening and potentially delay biological aging.
Mechanistically, vitamin D may exert these anti-aging effects by increasing telomerase activity, reducing DNA damage, and modulating inflammatory pathways via vitamin D receptor–dependent mechanisms.
Daily supplementation with 2,000 IU of vitamin D slows the rate of telomere shortening, preserving telomere length equivalent to delaying ~3 years of biological aging over four years.
one of the interesting things about vitamin D is that it has been shown to regulate the aging process telomeres are tiny caps at the end of your chromosomes that protect your DNA from damage you can sort of think about telomeres like the tips of shoelaces they protect them from fraying every year our telomeres get shorter and shorter until eventually they burn off and our cells die or they go into a permanent state of arrest so telomere length is actually a biological marker for aging now here's where vitamin D enters to epidemiological studies on twins found at those individuals with the lowest levels of vitamin D also had the shortest telomeres and this telomere shortening correlated to five years of biological aging
it's thought that the anti-inflammatory properties of vitamin D are partly responsible for delaying the attrition of telomere length
vitamin D can actually protect DNA tiir or caps at the end of your DNA that protect it from unwinding and they decrease every year with age vitamin D can actually protect tiir length
well it's been found in twins that those twins with the highest levels of vitamin D have the longest tiir compared to those twins with the lowest levels of vitamin D in fact those levels corresponded to five years of biological aging so though even though they were the same chronological age those twins that had the lowest levels of vitamin D their cells looked 5 years older
Other Studies have shown that people that have serum levels of 25 hydroxy vitamin D between 40 and 60 nanograms per milliliter have the lowest all cause mortality and also have the longest tumer length
Actually, people that have low vitamin D have shorter telomeres
So I think there is certainly a lot of evidence associative studies and also there's some randomized-control trials that really does point to the fact that vitamin D is regulating the aging process. It's been shown to regulate telomere length.
I think vitamin D...there was another one also with vitamin D correct where there was a sweet spot of vitamin D levels. I think it was something like 40 to 60 nanograms per mil which was associated with better telomere length as well.