Individuals with Alzheimer's disease had substantially higher APOE4 prevalence compared to non-Alzheimer's patients in the late 1980s.

“so around 1988-89 a researcher at duke by the name of allen roses was running an alzheimer's group and had access to a very robust at that time robust enough obviously now it's not robust at all but he had the ability to genetically profile a large number of common variants of people dying with and without alzheimer's at that point in time he publishes a case series a few hundreds with and without alzheimer's and identifies that patients with alzheimer's has substantially higher apoe4 compared to non-alzheimer's”