Andrew Huberman· PhD
one of the major features of age related cognitive decline and one that's greatly exacerbated in Alzheimer's is a breakdown of the bloodb brain barrier
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one of the major features of age related cognitive decline and one that's greatly exacerbated in Alzheimer's is a breakdown of the bloodb brain barrier
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The aging process and other lifestyle factors (ie. sedentary) break down the blood-brain barrier and this results in a vicious cycle of neuroinflammation that can lead to dementia and Alzheimer's disease.
This early stage can be identified well before the appearance of traditional Alzheimer's biomarkers like tau tangles and amyloid plaques.
Remarkably, about 50% of all dementia cases, including Alzheimer's, start with the degradation of the blood-brain barrier.
just the fact that we age normally the vessels start to be normally dysfunctional as we age like the whole body it's not only the brain just not only the vessels we are just aging and these vessels we we've developed a way to to measure how leaky uh if I can use that term which is easy to understand so everyone hardly key meaning that things from the blood can leak out to the brain and we can measure that with magnetic resonance imaging MRI so we developed that technique in the U.S and California and the University of Southern California where we can really detect small deakiness of the Broadband barrier