Carriers of two copies of APOE4 have a 12-fold increased chance of developing Alzheimer's disease, while carriers of one copy have a two to four-fold increased chance.

“particularly gonna live a long life in the environment that we live in it certainly seems to be a significant risk factor”

“if you look across the population broadly apoe4 is associated with a higher risk of dementia specifically alzheimer's”

“In westernized populations um Apple E4 is the or you know having one or more copies of of um Apple E4 is you know the most important single genetic risk factor for age-related dementia we'll call it it contributes a you know maybe up to five percent of total risk your apoe for your apoe genotype and you know compared to um those who don't have apoe for so either tutus or three threes or two threes um the the you get an increased odds of uh developing age-related dementia of maybe you know six to twenty fold higher”

“so what we know now is that if you have two copies of ape-4 your chance of getting alzheimer's increases 12-fold if you have one copy of apoe4 your chance of having alzheimer's increases anywhere from two to four-fold”

“well we know having an apoe4 allele so this is a version of a gene that is known to increase the risk of Alzheimer's disease if you have one of them it increases the risk twofold if you have two if you got one from Mom and one from Dad it could be up to tenfold and this isn't like an early onset Alzheimer's disease it's it's more of what's called late onset which is the normal sort of age-related you know progression of Alzheimer's disease but that Gene really does play a role in in in you know in someone's risk”

“People who have two copies of the four are at significantly higher risk for Alzheimer's disease about 10 times higher risk”

“people who have two copies of the four four are at significantly higher risk for Alzheimer's disease about 10 times higher risk”

“And I found out that I have one copy of this of this allele. And when I found that out years ago, I was like...it's probably the biggest risk factor for late-onset on Alzheimer's disease besides age. Yes, So I think one of those alleles, it's about sorts of two to threefold risk. If you have two of them, it's like an 8 to 12.”

“having one copy of this ape4 a elevates Alzheimer's risk around twofold compared to having no copies and having two copies of the apoe4 AIL can increase the risk of Alzheimer's disease up to tfold”

“Having one alil can increase the risk of dementia, Alzheimer's disease by twofold. Having two copies of that alil can increase the risk up to 10fold.”