Rhonda Patrick· PhD
and the combined contribution of ε3 and ε4 to all-cause dementia is roughly 46%.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
and the combined contribution of ε3 and ε4 to all-cause dementia is roughly 46%.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Still, the scale of these estimates makes it clear that APOE biology is a dominant driver of Alzheimer’s risk at the population level.
A new, large-scale analysis reports that up to 93% of Alzheimer’s cases and 85% of brain amyloid burden are attributable to having an APOE ε3/ε4 genotype