Peter Attia· MD
the main problem in the Alzheimer's brain had to do with this inhibition of cytochrome oxidase
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the main problem in the Alzheimer's brain had to do with this inhibition of cytochrome oxidase
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these phenomena are coupled as soon as you have hypoxia it's came here you reduce then this machinery goes down regulated is that true of complex one two three as well are they also inducible the way complex four is not as much as conflict for they are to certain degree if you keep taxing the system it's going to happen but the one that has the more flexibility from more immediate to long-term because of this role has really limiting is complex for and that's the reason it is preferred model later of the system that's why I love doing these podcasts every single podcast I get to learn something new in biology that I didn't know I had no idea that complex four was inducible to a greater extent on the others has it ease for example you may have her for sure during your training about all the usable in science yes of course the cytochrome systems yes in the liver so the labor is p450 the people so it's a perfect example you know if you have more talk if you drink more alcohol you're gonna build up more of these cytochrome enzyme so these are the most inducible in somatic complexes that we have you just never think of it in something so important not that the liver is less important of course but the e.t.c is so fundamental for everything that we do it's so interesting to think of that and it's also interesting to hear you say that at least in transient periods of ischemia this is not irreversible no he's not reversible is an inducible citizen just like your stops like delivers you thinking alcohol these enzymes are gonna be down regulated but if you start challenging the system ain't they they are inducible they're gonna go back of course you're gonna suffer somewhat in between because at the beginning you're not gonna be able to meet the demand but it they aren't useful and this is the key that I have understood from our investigation of the Alzheimer's brain in those fresh frosting Alzheimer's reign the main problem was cytochrome oxidase innovation the levels of the protein levels of the EM sighs were not compromised but you could see that the enzyme was not in his catalytic functional state and you could demonstrate these doing enzyme histo chemistry